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MMP13 protein, human

Known as: CLG3 protein, human, Matrix Metalloprotease 13, Matrix Metalloproteinase 13 
Collagenase 3 (471 aa, ~54 kDa) is encoded by the human MMP13 gene. This protein plays a role in the proteolysis of the extracellular matrix.
National Institutes of Health

Related topics

Related topics

12 relations
COLLAGENASEEnzyme GeneExtracellular Matrix DegradationExtracellular Space

Broader (1)

Matrix Metalloproteinase 13

Papers overview

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Highly Cited
2008
Highly Cited
2008
Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
OBJECTIVE Abnormal subchondral bone metabolism is involved in osteoarthritis (OA). It has been suggested that ephrin B2 and its… 
2008
2008
Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis.
2007
2007
Contributions of matrix metalloproteinases toward Meckel’s cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones
The middle portion of Meckel’s cartilage (one of four portions that disappear with unique fate) degrades via hypertrophy and the… 
2006
2006
Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration—an in vivo study on the New Zealand white rabbit
The objective of the study was to improve the biological understanding of degenerative disc disease using a rabbit model in which… 
2006
2006
Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.
2005
2005
P253R fibroblast growth factor receptor‐2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation
Unregulated fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2… 
Highly Cited
2002
Highly Cited
2002
Expression of collagenase‐3 (MMP‐13) enhances invasion of human fibrosarcoma HT‐1080 cells
Collagenase‐3 (MMP‐13) is characterized by an exceptionally wide substrate specificity and restricted expression. MMP‐13 is 1 of… 
Review
2000
Review
2000
Calcium crystal effects on the cells of the joint: implications for pathogenesis of disease.
In the past three years, there has been considerable progress in delineating the mechanism of calcium-containing crystal-induced… 
1999
1999
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in joint fluid of the patients with loose artificial hip joints.
The pseudojoint cavity formed in patients undergoing total hip arthroplasty (THA) is later remodeled to synovial membrane-like… 
1996
1996
Regulation of rat interstitial collagenase gene expression in growth cartilage and chondrocytes by vitamin D3, interleukin‐1β, and okadaic acid
The interstitial collagenase produced by the rat growth plate chondrocytes is the homologue of the human collagenase‐3, or matrix… 
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