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MMP13 gene

Known as: CLG3, MATRIX METALLOPROTEINASE 13, Matrix Metallopeptidase 13 (Collagenase 3) Gene 
This gene plays a role in proteolysis of collagen.
National Institutes of Health

Related topics

Related topics

7 relations
Extracellular Matrix DegradationHydrolysisMMP-13 activityMMP13 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Association of MMP9-1562C/T and MMP13-77A/G Polymorphisms with Non-Small Cell Lung Cancer in Southern Chinese Population
Background: Matrix metalloproteinases (MMPs) are capable of degrading and modifying most components of the extracellular matrix… 
2017
2017
LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
Reduced SIRT1 activity and levels during osteoarthritis (OA) promote gradual loss of cartilage. Loss of cartilage matrix is… 
Highly Cited
2014
Highly Cited
2014
Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
IntroductionRecent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of… 
Highly Cited
2014
Highly Cited
2014
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice
IntroductionPrevious observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it… 
Highly Cited
2013
Highly Cited
2013
A Feedback Inhibition between miRNA-127 and TGFβ/c-Jun Cascade in HCC Cell Migration via MMP13
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and is increasing in frequency in the U.S. The major… 
Highly Cited
2012
Highly Cited
2012
Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.
OBJECTIVE To identify mechanisms by which Smad3 maintains articular cartilage and prevents osteoarthritis. METHODS A… 
Highly Cited
2012
Highly Cited
2012
Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral…
Background: Molecular mechanisms controlling the late stages of endochondral ossification are unclear. Results: Osterix functions… 
Highly Cited
2009
Highly Cited
2009
Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia.
Highly Cited
2002
Highly Cited
2002
Gene Expression of MMP8 and MMP13 During Embryonic Development of Bone and Cartilage in the Rat Mandible and Hind Limb
Matrix metalloproteinases (MMPs) 8 and 13 comprise the collagenase subfamily in rats and mice, and only MMP13 has been implicated… 
Highly Cited
2002
Highly Cited
2002
MMP13 promoter polymorphism is associated with atherosclerosis in the abdominal aorta of young black males.
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