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Autophagy modulates osteoarthritis-related gene expression in human chondrocytes.
OBJECTIVE Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism. The purpose of this study was to elucidate the roleExpand
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Use of an antifibrotic agent improves the effect of platelet-rich plasma on muscle healing after injury.
BACKGROUND Muscle contusions are a common type of muscle injury and are frequently encountered in athletes and military personnel. Although these injuries are capable of healing in most instances,Expand
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Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
IntroductionRecent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injectionExpand
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The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
In this study, we examined the effects of overexpression of SIRT1 on IL‐1β‐induced gene expression changes in human chondrocytes to explore a protective role of SIRT1 in human chondrocytes. SIRT1 wasExpand
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A radiographic analysis of alignment of the lower extremities--initiation and progression of varus-type knee osteoarthritis.
OBJECTIVE This study aimed to investigate alignment based on age in normal knees and alignment based on deformity in osteoarthritis (OA) knees using detailed radiographic parameters. DESIGN VariousExpand
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Factors affecting quadriceps strength recovery after anterior cruciate ligament reconstruction with hamstring autografts in athletes
PurposePatients typically return to sports activities 6–12 months after anterior cruciate ligament (ACL) reconstruction, and quadriceps strength has been used as one of the criteria to return toExpand
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Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
Objectives Important roles for SIRT1 are implicated in ageing and age-related diseases. The role of SIRT1 in osteoarthritis (OA), however, remains partially unknown. To investigate the role of SIRT1Expand
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Radiological and clinical comparison of kinematically versus mechanically aligned total knee arthroplasty
Aims The aim of this study was to compare the post‐operative radiographic and clinical outcomes between kinematically and mechanically aligned total knee arthroplasties (TKAs). Patients and Methods AExpand
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SIRT1 regulation of apoptosis of human chondrocytes.
OBJECTIVE SIRT1 is known to inhibit apoptosis and to promote survival of various types of cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been reported. We undertookExpand
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Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes.
OBJECTIVE SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases. However,Expand
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