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- Publications
- Influence
Autophagy modulates osteoarthritis-related gene expression in human chondrocytes.
- H. Sasaki, K. Takayama, +7 authors R. Kuroda
- Biology, Medicine
- Arthritis and rheumatism
- 1 June 2012
OBJECTIVE
Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism. The purpose of this study was to elucidate the role… Expand
Use of an antifibrotic agent improves the effect of platelet-rich plasma on muscle healing after injury.
- Satoshi Terada, S. Ota, +9 authors J. Huard
- Medicine
- The Journal of bone and joint surgery. American…
- 5 June 2013
BACKGROUND
Muscle contusions are a common type of muscle injury and are frequently encountered in athletes and military personnel. Although these injuries are capable of healing in most instances,… Expand
Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
- K. Takayama, Y. Kawakami, +7 authors J. Huard
- Medicine
- Arthritis Research & Therapy
- 17 November 2014
IntroductionRecent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection… Expand
The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
- T. Matsushita, H. Sasaki, +7 authors R. Kuroda
- Chemistry, Medicine
- Journal of orthopaedic research : official…
- 1 April 2013
In this study, we examined the effects of overexpression of SIRT1 on IL‐1β‐induced gene expression changes in human chondrocytes to explore a protective role of SIRT1 in human chondrocytes. SIRT1 was… Expand
A radiographic analysis of alignment of the lower extremities--initiation and progression of varus-type knee osteoarthritis.
- T. Matsumoto, M. Hashimura, +7 authors M. Kurosaka
- Medicine
- Osteoarthritis and cartilage
- 1 February 2015
OBJECTIVE
This study aimed to investigate alignment based on age in normal knees and alignment based on deformity in osteoarthritis (OA) knees using detailed radiographic parameters.
DESIGN
Various… Expand
Factors affecting quadriceps strength recovery after anterior cruciate ligament reconstruction with hamstring autografts in athletes
- Y. Ueda, T. Matsushita, +10 authors R. Kuroda
- Medicine
- Knee Surgery, Sports Traumatology, Arthroscopy
- 1 October 2017
PurposePatients typically return to sports activities 6–12 months after anterior cruciate ligament (ACL) reconstruction, and quadriceps strength has been used as one of the criteria to return to… Expand
Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- T. Matsuzaki, T. Matsushita, +4 authors M. Kurosaka
- Medicine
- Annals of the rheumatic diseases
- 30 May 2013
Objectives Important roles for SIRT1 are implicated in ageing and age-related diseases. The role of SIRT1 in osteoarthritis (OA), however, remains partially unknown. To investigate the role of SIRT1… Expand
Radiological and clinical comparison of kinematically versus mechanically aligned total knee arthroplasty
- T. Matsumoto, K. Takayama, K. Ishida, S. Hayashi, S. Hashimoto, R. Kuroda
- Medicine
- The bone & joint journal
- 1 May 2017
Aims The aim of this study was to compare the post‐operative radiographic and clinical outcomes between kinematically and mechanically aligned total knee arthroplasties (TKAs). Patients and Methods A… Expand
SIRT1 regulation of apoptosis of human chondrocytes.
- K. Takayama, K. Ishida, +9 authors R. Kuroda
- Biology, Medicine
- Arthritis and rheumatism
- 1 September 2009
OBJECTIVE
SIRT1 is known to inhibit apoptosis and to promote survival of various types of cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been reported. We undertook… Expand
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes.
- K. Nagai, T. Matsushita, +4 authors M. Kurosaka
- Biology, Medicine
- Osteoarthritis and cartilage
- 1 April 2014
OBJECTIVE
SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases. However,… Expand
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