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Mannomustine

Known as: D-Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, Mannitol Nitrogen Mustard, Mannomustine [Chemical/Ingredient] 
A nitrogen mustard derivative that cross-links with DNA, causing inhibition of DNA synthesis. It may be used to treat certain cancers, but may cause… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (1)

Antineoplastic Agents, Alkylating

Narrower (2)

DegranolMannomustine Hydrochloride
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Some effects of 1-methyl-2-p-(isopropyl-carbamoyl)-benzyl-hydrazine and mannomustine on the metabolism of human erythrocytes in vitro.
During incubation of erythrocytes with Natulan® and Degranol® a depression of the concentrations of reduced glutathione and… 
1989
1989
A pharmacological approach to cellular mechanisms of PGI2-induced gastric cytoprotection on ethanol-induced gastric mucosal damage in rats.
The aims of this study were as follows: 1. to analyse the effects of drugs with different subcellular mechanisms on the PGI2… 
1978
1978
PROLONGATION OF RAT CARDIAC ALLOGRAFT SURVIVAL BY DONOR PRETREATMENT: SCREENING OF ANTINEOPLASTIC DRUGS
SUMMARY We have made preliminary investigations into the effect of 33 different drugs on the survival of rat cardiac allografts… 
1975
1975
The effect of cytostatic hexitol derivatives on haematopoietic stem cells, the L1210 leukaemia and C22LR osteosarcoma.
Review
1974
Review
1974
Lymphocyte deactivation by (potential immunosuppressant) alkylating metabolites of cyclophosphamide
SummaryThe potential immunosuppressant activity of the following compounds derived from cyclophosphamide (CPA) was evaluated: 8… 
1969
1969
Effect of various nucleic acid and protein synthesis inhibitors on anaphylactoid inflammation in rats.
1969
1969
Effect of mannitol mustard (NSC-9698) on nuclear DNA content and birefringence of Hela and Chinese hamster cells.
1962
1962
[Comparative studies on the effect of dimethanesulfonyl-D-mannitol and mannitol mustard on animal leukemia].
1960
1960
Comparative clinical evaluation of two alkylating agents: mannitol mustard and cyclophosphamide (cytoxan).
An intensive search for agents of increased therapeutic benefit in the treatment of neoplastic disease has prompted the… 
1959
1959
Mannomustine in Treatment of Leukaemias, Polycythaemia, and Malignant Disorders
Baldwin, E. deF., Cournand, A., and Richards, D. W., jun. (1949). Medicine (Baltimore), 28, 201. Buechley, R. W., Drake, R. M… 
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