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Thiocyanate and chloride as competing substrates for myeloperoxidase.
Thiocyanate is a major physiological substrate of myeloperoxidase, regardless of where the enzyme acts, and more consideration should be given to the oxidation products of thiOCyanate and to the role they play in host defence and inflammation. Expand
Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel
Data show Lyprinol to be a reproducible, relatively stable, source of bioactive lipids with much greater potency than plant/marine oils currently used as nutritional supplements to ameliorate signs of inflammation. Expand
Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparation.
Freeze-dried powdered preparations of whole (i.e. without shell) green-lipped mussel from New Zealand given orally to rats showed some modest anti-inflammatory activity and strikingly reduced the gastric ulcerogenicity of several non-steroid anti- inflammatory drugs in rats and pigs. Expand
Emu oil(s): A source of non-toxic transdermal anti-inflammatory agents in aboriginal medicine
The ‘oil’ obtained from emu fat can be a very effective inhibitor of chronic inflammation in rats when applied dermally (with a skin penetration enhancer) but the need for more rigid quality control before considering such a (now proven) traditional medicine as a complementary therapy is pointed to. Expand
Anti-inflammatory activity of emu oils in rats
Four of the preparations of emu oil were found to be active against adjuvant-induced arthritis in rats, and the efficacies of the emu oils acting transdermally are compared with that of orally administered ibuprofen. Expand
D‐Tyrosine as a Chiral Precusor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A2 (IIa) with Antiinflammatory Activity
The simple chiral precursor D‐tyrosine was derivatised to give a series of potent new inhibitors of hnpsPLA2‐IIa, which inhibit the IIa human isoform noncovalently at submicromolar concentrations. Expand
Effect of Ion Pairing with Alkylamines on the In‐vitro Dermal Penetration and Local Tissue Disposition of Salicylates
The value of forming ion pairs between anionic salicylate and a series of amines as model cationic counter‐ions to facilitate topical delivery and skin penetration is examined. Expand
Anti-Inflammatory Drugs
Treating inflammation: some (needless) difficulties for gaining acceptance of effective natural products and traditional medicines
Beyond the verifiable science, the healing professions and the general public still need to examine more carefully criteria for QUALITY(S) in any alternative medicine to ensure the good (= both reputations and products) are not destroyed by the bad—in essence counteracting Gresham's Law. Expand
Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.
Over a hundred compounds and natural materials were examined for their ability to induce arthritis in rats when mixed with heat-killed delipidated Mycobacteria tuberculosis, and squalane, pristane and hexadecane were excellent substitutes for mineral oil in preparing arthritogenic adjuvants from various mycob bacteria, C. rubrum and N. asteroides. Expand