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Molecular comparison of calcineurin inhibitor-induced fibrogenic responses in protocol renal transplant biopsies.
- Marian C Roos-van Groningen, E. Scholten, +9 authors M. Eikmans
- Journal of the American Society of Nephrology…
- 1 March 2006
It is concluded that the fibrogenic response in renal allografts is similar in patients who receive CsA-based regimens and patients who are subjected to tacrolimus- based regimens. Expand
Cell-cycle specificity and therapeutic effectiveness of cytostatic agents.
Acetyldinaline: a new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells--preclinical studies in a relevant rat model for human acute myelocytic…
The impressive differential activity against leukemic cells and normal stem cells observed in this relevant rat model for human acute myelocytic leukemia warrants the introduction of this compound in clinical phase I/II studies. Expand
Factors determining cell killing by chemotherapeutic agents in vivo. II. Melphalan, chlorambucil and nitrogen mustard.
It is suggested that repair of damaged DNA, by excision of alkylated bases or oligonucleotides before the damage becomes irreversible during the next DNA synthetic period, is the most likely explanation of the uniform difference in sensitivity caused by the modified rate of cell proliferation. Expand
In vitro antiproliferative activity of docetaxel (Taxotere), paclitaxel (Taxol) and cisplatin against human tumour and normal bone marrow cells.
In all comparisons docetaxel and paclitaxel were much more potent than cisplatin with IC50 values of the taxoids being in the nanomolar range, indicating that no cross-sensitivity exists between cis platin and both taxoids. Expand
Experimental studies on the combination of radiation and chemotherapy.
Experimental studies were performed to evaluate the effect of approximately simultaneous application of radiation and a number of widely used cytostatic agents and so far no agent was identified which showed potentiation in all malignant cell systems tested. Expand
Preclinical studies on toxicity, antitumour activity and pharmacokinetics of cisplatin and three recently developed derivatives.
- P. Lelieveld, W. van der Vijgh, +4 authors A. Danguy
- Chemistry, Medicine
- European journal of cancer & clinical oncology
- 1 August 1984
All three derivatives were at least as toxic as CDDP for haemopoietic stem cells and were less active than CDDP against the mouse tumours leukaemia L1210 and osteosarcoma C22LR. Expand
The survival of colony-forming units in mouse bone-marrow after in vivo irradiation with D-T neutrons, X- and gamma-radiation.
- J. Broerse, A. C. Engels, +7 authors A. Howard
- Biology, Medicine
- International journal of radiation biology and…
From the combined results of both groups a mean RBE of 1·1 can be derived for low surviving fractions, owing to the difference in extrapolation numbers for x-rays and neutrons, the RBE depends on the level of survival. Expand
The effect of treatment in fractionated schedules with the combination of X-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin.
- P. Lelieveld, M. Scoles, J. Brown, R. Kallman
- International journal of radiation oncology…
RIF-1 tumors, implanted syngeneically in the gastrocnemius muscles of the right hind legs of C3H/Km mice, were treated either with X ray alone, drug alone, or drug and X ray combined, and seven different schedules of combined modalities were tested. Expand
Factors determining cell killing by chemotherapeutic agents in vivo. I. Cyclophosphamide.
The results show that only part of the difference in activity of cyclophosphamide versus normal bone marrow stem cells and tumour cells may be ascribed to differences in the rate of cell proliferation; other discriminating mechanisms must be involved. Expand