Manganese Superoxide Dismutase

Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD(+)-dependent histone/protein deacetylase, promotes… (More)

Superoxide dismutases are an ubiquitous family of enzymes that function to efficiently catalyze the dismutation of superoxide… (More)

Rat liver was homogenized in isotonic buffer, fractionated by differential centrifugation, and then subfractionated by… (More)

Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study… (More)

Recent studies have shown that release of mitochondrial cytochrome c is a critical step in the apoptosis process. We have… (More)

Several recently identified intracellular proteins associate with the tumor necrosis factor (TNF) receptor and activate nuclear… (More)

Peroxynitrite has recently been implicated in the inactivation of many enzymes. However, little has been reported on the… (More)

Mitochondrial injury has been implicated in ischemic neuronal injury. Mitochondria, producing adenosine triphosphate by virtue of… (More)

The transcription factor NF-kappaB is expressed in neurons wherein it is activated in response to a variety of stress- and injury… (More)

Manganese superoxide dismutase (MnSOD) has been previously shown to suppress the malignant phenotype of human melanoma and breast… (More)