SOD2 protein, human

Known as: Mitochondrial Superoxide Dismutase 2, Manangese Superoxide Dismutase, MNSOD 
Superoxide dismutase [Mn], mitochondrial (222 aa, ~25 kDa) is encoded by the human SOD2 gene. This protein plays a role in superoxide reduction.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
A major cause of aging and numerous diseases is thought to be cumulative oxidative stress, resulting from the production of… (More)
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Review
2006
Review
2006
Contraction-induced production of reactive oxygen species (ROS) has been shown to cause oxidative stress to skeletal muscle. As… (More)
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Highly Cited
2006
Highly Cited
2006
We previously proposed that the production of hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) is a key event… (More)
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Highly Cited
2004
Highly Cited
2004
Mutations in RAS2, CYR1, and SCH9 extend the chronological life span in Saccharomyces cerevisiae by activating stress-resistance… (More)
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Highly Cited
2003
Highly Cited
2003
Signal transduction pathways inactivated during periods of starvation are implicated in the regulation of longevity in organisms… (More)
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Highly Cited
2002
Highly Cited
2002
Reactive oxygen species are required for cell proliferation but can also induce apoptosis. In proliferating cells this paradox is… (More)
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Highly Cited
2001
Highly Cited
2001
Endothelial nitric oxide synthase (eNOS) is activated by phosphorylation of serine 1177 by the protein kinase Akt/PKB. Since… (More)
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Highly Cited
2001
Highly Cited
2001
Heart mitochondria from heterozygous (Sod2(-/+)) knockout mice have a 50% reduction in manganese superoxide dismutase (MnSOD… (More)
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Review
1998
Review
1998
Oxidative stress is a condition in which oxidant metabolites exert their toxic effect because of an increased production or an… (More)
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Highly Cited
1996
Highly Cited
1996
Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense… (More)
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