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MYLK gene

Known as: smMLCK, KINASE-RELATED PROTEIN, Myosin, Light Polypeptide Kinase Gene 
This gene plays a role in smooth muscle contraction.
National Institutes of Health

Related topics

Related topics

8 relations

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MYLK wt Allele
MYLK2 geneMuscle ContractionMyosin Light Chain KinasePhosphorylation

Papers overview

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Highly Cited
2002
Highly Cited
2002
Activation of Smooth Muscle Myosin Light Chain Kinase by Calmodulin
Calmodulin (CaM)-dependent myosin light chain kinase (MLCK) plays a key role in activation of smooth muscle contraction. A… 
Highly Cited
1998
Highly Cited
1998
Na+-K+-2Cl-cotransport in Ehrlich cells: regulation by protein phosphatases and kinases.
To identify protein kinases (PK) and phosphatases (PP) involved in regulation of the Na+-K+-2Cl-cotransporter in Ehrlich cells… 
Review
1998
Review
1998
Myosin light chain kinase: functional domains and structural motifs.
Conventional myosin light chain kinase found in differentiated smooth and non-muscle cells is a dedicated Ca2+/calmodulin… 
Highly Cited
1993
Highly Cited
1993
A kinase-related protein stabilizes unphosphorylated smooth muscle myosin minifilaments in the presence of ATP.
An apparent paradox in smooth muscle biology is the ability of unphosphorylated myosin to maintain a filamentous structure in the… 
Highly Cited
1991
Highly Cited
1991
Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets
Bile‐canaliculus contraction in rat hepatocyte doublets is postulated to involve activation of an actinmyosin system. We examined… 
Highly Cited
1987
Highly Cited
1987
Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.
Highly Cited
1986
Highly Cited
1986
Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase.
A protein kinase phosphorylation site in chicken gizzard myosin light chain kinase (MLCK) has been identified, and a synthetic… 
Highly Cited
1985
Highly Cited
1985
Interaction of calmodulin and a calmodulin-binding peptide from myosin light chain kinase: major spectral changes in both occur as the result of complex formation.
Many different enzymes are activated by direct interaction with calmodulin; this interaction is thought to occur through a… 
Highly Cited
1979
Highly Cited
1979
Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S]ATP gamma S.
Rabbit ileum strips were functionally skinned by exposure to staphylococcal alpha-toxin. Incubation of the strips in the ATP… 
Highly Cited
1978
Highly Cited
1978
Identification of an activator protein for myosin light chain kinase as the Ca2+-dependent modulator protein.
Myosin light chain kinase which phosphorylates g2 light chain of skeletal muscle myosin requires an activator for the activity… 
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