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MSLN gene

Known as: Mesothelin Gene, MPF, CAK1 
This gene may be involved in cellular adhesion.
National Institutes of Health

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Related topics

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Cell AdhesionImmune responseMSLN protein, humanmesothelin

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MSLN wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Phase I study of anti-mesothelin antibody drug conjugate anetumab ravtansine (AR).
2509Background: AR (BAY 94-9343) comprises a novel fully human anti-mesothelin IgG1 antibody conjugated to the maytansinoid… 
2016
2016
Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity
Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv… 
2016
2016
Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes
Recombinant immunotoxins (RITs) are antibody-based therapeutics that carry a toxin payload. The RG7787 RIT targets the cancer… 
2013
2013
Hyaluronan and N-ERC/Mesothelin as Key Biomarkers in a Specific Two-Step Model to Predict Pleural Malignant Mesothelioma
Purpose Diagnosis of malignant mesothelioma is challenging. The first available diagnostic material is often an effusion and… 
2013
2013
Utility of mesothelin, L1CAM and Afamin as biomarkers in primary ovarian cancer.
BACKGROUND We evaluated the prognostic value of the new serum biomarkers mesothelin (cell surface glycoprotein and tumor… 
2013
2013
Evaluation of Soluble Mesothelin-related Peptide as a Diagnostic Marker of Malignant Pleural Mesothelioma Effusions: Its Contribution to Cytology
Soluble mesothelin-related peptide (SMRP) is regarded as an FDA approved biomarker for the diagnosis and monitoring of pleural… 
2012
2012
Tissue and Serum Mesothelin Are Potential Markers of Neoplastic Progression in Barrett's Associated Esophageal Adenocarcinoma
Background: Mesothelin is overexpressed in several malignancies and is purportedly a specific marker of malignant transformation… 
2011
2011
Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with… 
2009
2009
Glomerular filtration rate is a confounder for the measurement of soluble mesothelin in serum.
The mesothelin gene encodes a 71-kDa precursor protein that is subsequently cleaved into a soluble megakaryocyte potentiating… 
2005
2005
Expression of Mesothelin mRNA in Pure Pancreatic Juice From Patients With Pancreatic Carcinoma, Intraductal Papillary Mucinous Neoplasm of the Pancreas, and Chronic Pancreatitis
Objectives: In the gene expression analysis of pancreatic carcinoma (PCa) using serial analysis of gene expression (SAGE… 
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