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mesothelin

Known as: CAK1 Antigen, Pre-Pro-Megakaryocyte-Potentiating Factor, megakaryocyte potentiating factor 
A protein found on the surface of certain types of normal cells and cancer cells. Mesothelin may help these cells stick together and send signals. A… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (1)

GPI-Linked Proteins
GlycoproteinsImmune System ProcessesLungMORAb-009 monoclonal antibody

Narrower (1)

MSLN protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Near infrared photoimmunotherapy with an anti-mesothelin antibody
Near Infrared-Photoimmunotherapy (NIR-PIT) is a new, highly selective tumor treatment that employs an antibody-photon absorber… 
2013
2013
Gene Expression Analyses Support Fallopian Tube Epithelium as the Cell of Origin of Epithelial Ovarian Cancer
Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous… 
2012
2012
Tissue and Serum Mesothelin Are Potential Markers of Neoplastic Progression in Barrett's Associated Esophageal Adenocarcinoma
Background: Mesothelin is overexpressed in several malignancies and is purportedly a specific marker of malignant transformation… 
Highly Cited
2009
Highly Cited
2009
The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC‐205/CD205 Receptor on Dendritic Cells
To develop a tumor vaccine directly targeting tumor antigen to dendritic cells in situ, we engineered human mesothelin (MSLN… 
Highly Cited
2009
Highly Cited
2009
A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity
Mesothelin is a potential new target for cancer immunotherapy because it is present at relatively low levels only in mesothelial… 
Highly Cited
2008
Highly Cited
2008
Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells
Pancreatic cancer is the fourth leading cause of cancer-related deaths in this country, and there is currently no effective… 
Highly Cited
2007
Highly Cited
2007
Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts
Purpose: To determine the antitumor activity of the anti–mesothelin immunotoxin SS1P in combination with gemcitabine against… 
2007
2007
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Recombinant immunotoxins exhibit targeting and cytotoxic functions needed for cell-specific destruction. However, antitumor… 
1999
1999
111Indium‐labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin
The monoclonal antibody (MAb) K1 is a murine IgG1 that recognizes mesothelin, a differentiation antigen present on mesothelium… 
Highly Cited
1982
Highly Cited
1982
Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line
This study demonstrates that an uncharacterized soluble factor produced in concanavalin A-induced rat spleen cell suspensions has… 
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