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mesothelin

Known as: CAK1 Antigen, Pre-Pro-Megakaryocyte-Potentiating Factor, megakaryocyte potentiating factor 
A protein found on the surface of certain types of normal cells and cancer cells. Mesothelin may help these cells stick together and send signals. A… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (1)

GPI-Linked Proteins
GlycoproteinsImmune System ProcessesLungMORAb-009 monoclonal antibody

Narrower (1)

MSLN protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Gene Expression Analyses Support Fallopian Tube Epithelium as the Cell of Origin of Epithelial Ovarian Cancer
Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous… 
2013
2013
Utility of mesothelin, L1CAM and Afamin as biomarkers in primary ovarian cancer.
BACKGROUND We evaluated the prognostic value of the new serum biomarkers mesothelin (cell surface glycoprotein and tumor… 
2013
2013
C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma
BackgroundLymph node metastasis is a key event of colorectal cancer (CRC) progression. Mesothelin is expressed in various types… 
2012
2012
Tissue and Serum Mesothelin Are Potential Markers of Neoplastic Progression in Barrett's Associated Esophageal Adenocarcinoma
Background: Mesothelin is overexpressed in several malignancies and is purportedly a specific marker of malignant transformation… 
2009
2009
Glomerular filtration rate is a confounder for the measurement of soluble mesothelin in serum.
The mesothelin gene encodes a 71-kDa precursor protein that is subsequently cleaved into a soluble megakaryocyte potentiating… 
Highly Cited
2008
Highly Cited
2008
Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells
Pancreatic cancer is the fourth leading cause of cancer-related deaths in this country, and there is currently no effective… 
Highly Cited
2007
Highly Cited
2007
Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts
Purpose: To determine the antitumor activity of the anti–mesothelin immunotoxin SS1P in combination with gemcitabine against… 
2007
2007
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Recombinant immunotoxins exhibit targeting and cytotoxic functions needed for cell-specific destruction. However, antitumor… 
Highly Cited
2005
Highly Cited
2005
Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy
Adenoviruses (Ads) are efficient gene transfer vehicles, but Ad-mediated gene therapy for ovarian cancer remains limited in vivo… 
Highly Cited
1982
Highly Cited
1982
Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line
This study demonstrates that an uncharacterized soluble factor produced in concanavalin A-induced rat spleen cell suspensions has… 
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