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MRS 2578

Known as: MRS-2578, MRS2578 
National Institutes of Health

Papers overview

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2020
2020
The Role of a Selective P2Y6 Receptor Antagonist, MRS2578, on the Formation of Angiotensin II-Induced Abdominal Aortic Aneurysms
Objective The P2Y6 receptor has been shown to be involved in many cardiovascular diseases, including hypertension and… 
2017
2017
P 2 Y 6 purinergic receptor regulates steroid synthesis and proliferation of ovarian luteal cells
Aim: As an important messenger, Uridine 5’-diphosphate (UDP) is involved in series of physiological and pathological processes… 
2016
2016
NET formation induced by gout-associated monosodium urate crystals requires IL-8-mediated neutrophil migration and is inhibited by the P2Y6 receptor antagonist MRS2578.
Human neutrophils generate inflammatory responses within the joints of gout patients upon encountering Monosodium Urate (MSU… 
2015
2015
Evidence for the existence of pyrimidinergic transmission in rat brain
2015
2015
UTP activates small-conductance Ca2+-activated K+ channels in murine detrusor PDGFRα+ cells.
Purines induce transient contraction and prolonged relaxation of detrusor muscles. Transient contraction is likely due to… 
2014
2014
Dual Role of P2 Receptors during Osteoblast Differentiation
P2 receptors activated by ATP are expressed in the skeletal system. However, the role of P2 receptors in osteoblast… 
2014
2014
Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice
2013
2013
Purine receptor P 2 Y 6 mediates cellular response to γ-ray-induced DNA damage
We previously showed that nucleotide P2 receptor agonists such as ATP and UTP amplify γ-ray-induced focus formation of… 
2012
2012
P2Y Receptors Regulate Proliferation of Human Pancreatic Duct Epithelial Cells
Objectives The aim of this study was to investigate the effect of P2Y receptor activation on proliferation of human pancreatic… 
2008
2008
Uridine diphosphate (UDP) stimulates insulin secretion by activation of P2Y6 receptors.
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