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MRS 2578

Known as: MRS-2578, MRS2578 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II–induced hypertension
Aging changes the response of blood vessels to angiotensin II, contributing to hypertension. Raising blood pressure with age… 
Highly Cited
2014
Highly Cited
2014
Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo
Microglia activated through Toll‐like receptor (TLR)‐2 or ‐4 can cause neuronal death by phagocytosing otherwise‐viable neurons—a… 
Highly Cited
2014
Highly Cited
2014
ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors.
Highly Cited
2014
Highly Cited
2014
Extracellular UDP and P2Y6 Function as a Danger Signal To Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-β Production
Extracellular nucleotides that constitute a “danger signal” play an important role in the regulation of immune responses. However… 
2014
2014
Enhancement of Glucose Uptake in Mouse Skeletal Muscle Cells and Adipocytes by P2Y6 Receptor Agonists
Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in the maintenance of glucose… 
Highly Cited
2012
Highly Cited
2012
Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury
A prominent signaling pathway in the development of neuropathic pain involves ATP acting on microglial purinergic receptors… 
Highly Cited
2011
Highly Cited
2011
Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation.
RATIONALE Extracellular nucleotides have recently been identified as proinflammatory mediators involved in asthma pathogenesis by… 
Highly Cited
2009
Highly Cited
2009
Concomitant activation of P2Y2 and P2Y6 receptors on monocytes is required for TLR1/2‐induced neutrophil migration by regulating IL‐8 secretion
Extracellular nucleotides regulate a variety of cellular responses involved in inflammation via the activation of P2 receptors… 
2008
2008
Uridine diphosphate (UDP) stimulates insulin secretion by activation of P2Y6 receptors.
Highly Cited
2004
Highly Cited
2004
Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.
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