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Thrombus aspiration during ST-segment elevation myocardial infarction.
TLDR
Routine thrombus aspiration before PCI as compared with PCI alone did not reduce 30-day mortality among patients with STEMI, and results were consistent across all major prespecified subgroups, including subgroups defined according toThrombus burden and coronary flow before PCI.
Targeted temperature management at 33°C versus 36°C after cardiac arrest.
TLDR
In unconscious survivors of out-of-hospital cardiac arrest of presumed cardiac cause, hypothermia at a targetedTemperature of 33°C did not confer a benefit as compared with a targeted temperature of 36°C.
Instantaneous Wave‐free Ratio versus Fractional Flow Reserve to Guide PCI
TLDR
Among patients with stable angina or an acute coronary syndrome, an iFR‐ guided revascularization strategy was noninferior to an FFR‐guided revascularized strategy with respect to the rate of major adverse cardiac events at 12 months.
ADP Receptor P2Y12 Is Expressed in Vascular Smooth Muscle Cells and Stimulates Contraction in Human Blood Vessels
TLDR
Stable drugs with antagonistic effects on P2Y12 receptors, affecting both platelets and VSMC, could be of double therapeutic benefit in their prevention of both thrombosis and vasospasm.
P2 receptors in cardiovascular regulation and disease
TLDR
The dual role of ATP in regulation of vascular tone, released as a cotransmitter from sympathetic nerves or released in the vascular lumen in response to changes in blood flow and hypoxia is considered.
Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be
TLDR
A distinct and rapid increase in levels of cardiospecific miRNA in the circulation after myocardial infarction is demonstrated, indicating a possible role for these molecules as biomarkers for the diagnosis of STEMI as well as the prediction of long-term complications.
P2 Receptor Expression Profiles in Human Vascular Smooth Muscle and Endothelial Cells
TLDR
P2X1, P2y2, and P2Y6 are the most expressed P2 receptors in SMC and are thus probably mediating the contractile and mitogenic actions of extracellular nucleotides, and are most likely mediating release of nitric oxide, endothelium-dependent hyperpolarizing factor (EDHF), and t-PA induced by extrace cellular nucleotide.
Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary
TLDR
In aspirin-treated subjects with coronary artery disease, prasugrel 60/10 mg provides faster onset and greater inhibition of P2Y(12) receptor-mediated platelet aggregation than clopidogrel 600/75 mg, because of greater and more efficient generation of the active metabolite.
Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial
TLDR
Ticagrelor, when compared with clopidogrel, reduced ischaemic events in ACS patients irrespective of diabetic status and glycaemic control, without an increase in major bleeding events.
Platelets synthesize large amounts of active plasminogen activator inhibitor 1.
TLDR
There is a continuous production of large amounts of active PAI-1 in platelets, which could be a mechanism by which platelets contribute to stabilization of blood clots.
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