Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Ziconotide for treatment of severe chronic pain
- A. Schmidtko, J. Lötsch, R. Freynhagen, G. Geisslinger
- Medicine
- The Lancet
- 1 May 2010
Pharmacological management of severe chronic pain is difficult to achieve with currently available analgesic drugs, and remains a large unmet therapeutic need. The synthetic peptide ziconotide has… Expand
No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing
- A. Schmidtko, I. Tegeder, G. Geisslinger
- Medicine
- Trends in Neurosciences
- 1 June 2009
A large body of evidence indicates that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) essentially contribute to the processing of nociceptive signals in the spinal cord. Many animal… Expand
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
- I. Tegeder, S. Grösch, +5 authors G. Geisslinger
- Biology, Medicine
- Cancer research
- 15 April 2003
Opioid effects on tumor growth have been a controversial topic of discussion. In the present study, morphine inhibited tumor cell proliferation at concentrations of >or=10 micro M. This was primarily… Expand
NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury
- Wiebke Kallenborn-Gerhardt, K. Schroeder, +8 authors A. Schmidtko
- Medicine
- The Journal of Neuroscience
- 25 July 2012
Reactive oxygen species (ROS) contribute to sensitization of pain pathways during neuropathic pain, but little is known about the primary sources of ROS production and how ROS mediate pain… Expand
Celecoxib loses its anti‐inflammatory efficacy at high doses through activation of NF‐κB
- E. Niederberger, I. Tegeder, +6 authors G. Geisslinger
- Medicine
- FASEB journal : official publication of the…
- 1 July 2001
Celecoxib, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has recently been approved for the symptomatic treatment of arthritis. In some clinical studies, doses of 400 and 800 mg/day provided… Expand
Tissue distribution of imipenem in critically ill patients
- I. Tegeder, A. Schmidtko, L. Bräutigam, A. Kirschbaum, G. Geisslinger, J. Lötsch
- Medicine
- Clinical pharmacology and therapeutics
- 1 May 2002
Imipenem is a broad‐spectrum antibiotic used mainly for serious infections in critically ill patients. Because the infection originates mostly from a certain tissue, we assessed tissue concentrations… Expand
Cysteine-Rich Protein 2, a Novel Downstream Effector of cGMP/cGMP-Dependent Protein Kinase I-Mediated Persistent Inflammatory Pain
- A. Schmidtko, W. Gao, +11 authors G. Geisslinger
- Medicine
- The Journal of Neuroscience
- 6 February 2008
The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important role in spinal nociceptive processing. However, downstream targets of cGKI in this context have not been… Expand
Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats
- I. Tegeder, A. Schmidtko, E. Niederberger, P. Ruth, G. Geisslinger
- Chemistry, Medicine
- Neuroscience Letters
- 31 October 2002
The rat formalin assay was used to assess effects of the cyclic guanosine mono-phosphate (cGMP) analog, 8-bromo-cGMP on nociception and cGMP dependent protein kinase I (protein kinase G; PKG-I)… Expand
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.
- A. Schmidtko, W. Gao, +9 authors G. Geisslinger
- Medicine, Biology
- The Journal of neuroscience : the official…
- 20 August 2008
A large body of evidence indicates that the release of nitric oxide (NO) is crucial for the central sensitization of pain pathways during both inflammatory and neuropathic pain. Here, we investigated… Expand
NOXious signaling in pain processing.
- Wiebke Kallenborn-Gerhardt, K. Schroeder, G. Geisslinger, A. Schmidtko
- Chemistry, Medicine
- Pharmacology & therapeutics
- 1 March 2013
Chronic pain affects millions of people and often causes major health problems. Accumulating evidence indicates that the production of reactive oxygen species (ROS), such as superoxide anion or… Expand