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MK-886

Known as: MK 886, MK886 cpd 
 
National Institutes of Health

Papers overview

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2010
2010
BACKGROUND AND PURPOSE Certain 5‐lipoxygenase (5‐LO) inhibitors exhibit anti‐carcinogenic activities against 5‐LO overexpressing… Expand
Highly Cited
2006
Highly Cited
2006
Background  Recent reports point to an important role of leukotrienes in atherogenesis. Leukotrienes are produced by 5… Expand
Highly Cited
2005
Highly Cited
2005
A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the… Expand
Highly Cited
1997
Highly Cited
1997
Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene… Expand
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Highly Cited
1994
Highly Cited
1994
Leukotriene (LT) C4 synthase, an integral microsomal membrane protein, conjugates LTA4, an epoxide intermediate, to reduced… Expand
Highly Cited
1993
Highly Cited
1993
To elucidate the role of leukotrienes (LT) in allergic asthma in humans the effect of MK-886, an LT biosynthesis inhibitor, was… Expand
Highly Cited
1991
Highly Cited
1991
Leukotriene (LT)B4 promotes leukocyte chemotaxis and adhesion to the endothelium of postcapillary venules. The cysteinyl… Expand
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Highly Cited
1990
Highly Cited
1990
LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… Expand
Highly Cited
1990
Highly Cited
1990
Recently, we have shown that ionophore activation of human leukocytes results in leukotriene synthesis and a translocation of 5… Expand
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Highly Cited
1989
Highly Cited
1989
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… Expand