Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,023,958 papers from all fields of science
Search
Sign In
Create Free Account
MK-886
Known as:
MK 886
, MK886 cpd
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
3 relations
Broader (2)
Indoles
Lipoxygenase Inhibitors
L 663536
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.
Jilly F. Evans
,
A. Ferguson
,
R. Mosley
,
J. Hutchinson
TIPS - Trends in Pharmacological Sciences
2008
Corpus ID: 205406006
Highly Cited
2006
Highly Cited
2006
Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors ( , / , ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate
Margy L. Takacs
,
B. Abbott
2006
Corpus ID: 64617403
This study evaluates the potential for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) to activate peroxisome…
Expand
Highly Cited
2006
Highly Cited
2006
Inhibition of five lipoxygenase activating protein (FLAP) by MK‐886 decreases atherosclerosis in apoE/LDLR‐double knockout mice
J. Jawień
,
M. Gajda
,
+6 authors
R. Korbut
European Journal of Clinical Investigation
2006
Corpus ID: 44897529
Background Recent reports point to an important role of leukotrienes in atherogenesis. Leukotrienes are produced by 5…
Expand
Highly Cited
1997
Highly Cited
1997
Inhibition by boswellic acids of human leukocyte elastase.
H. Safayhi
,
B. Rall
,
E. Sailer
,
H. Ammon
Journal of Pharmacology and Experimental…
1997
Corpus ID: 34689802
Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene…
Expand
Highly Cited
1993
Highly Cited
1993
5‐lipoxygenase‐activating protein is an arachidonate binding protein
J. Mancini
,
M. Abramovitz
,
+6 authors
P. Vickers
FEBS Letters
1993
Corpus ID: 41137062
Highly Cited
1993
Highly Cited
1993
Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses.
B. Friedman
,
E. Bel
,
+5 authors
P. Sterk
American Review of Respiratory Disease
1993
Corpus ID: 37334233
To elucidate the role of leukotrienes (LT) in allergic asthma in humans the effect of MK-886, an LT biosynthesis inhibitor, was…
Expand
Highly Cited
1990
Highly Cited
1990
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
R. Dixon
,
R. Diehl
,
+5 authors
D. K. Miller
Nature
1990
Corpus ID: 4326434
LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory…
Expand
Highly Cited
1990
Highly Cited
1990
MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.
C. Rouzer
,
A. Ford-hutchinson
,
H. Morton
,
J. Gillard
Journal of Biological Chemistry
1990
Corpus ID: 19881648
Highly Cited
1990
Highly Cited
1990
Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.
G. Reid
,
S. Kargman
,
+7 authors
J. Evans
Journal of Biological Chemistry
1990
Corpus ID: 11030731
Highly Cited
1989
Highly Cited
1989
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
J. Gillard
,
A. Ford-hutchinson
,
+7 authors
H. Morton
Canadian Journal of Physiology and Pharmacology
1989
Corpus ID: 1209424
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE