MK-886

BACKGROUND AND PURPOSE Certain 5‐lipoxygenase (5‐LO) inhibitors exhibit anti‐carcinogenic activities against 5‐LO overexpressing… Expand

Background  Recent reports point to an important role of leukotrienes in atherogenesis. Leukotrienes are produced by 5… Expand

A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the… Expand

Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene… Expand

Leukotriene (LT) C4 synthase, an integral microsomal membrane protein, conjugates LTA4, an epoxide intermediate, to reduced… Expand

To elucidate the role of leukotrienes (LT) in allergic asthma in humans the effect of MK-886, an LT biosynthesis inhibitor, was… Expand

Leukotriene (LT)B4 promotes leukocyte chemotaxis and adhesion to the endothelium of postcapillary venules. The cysteinyl… Expand

LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… Expand

Recently, we have shown that ionophore activation of human leukocytes results in leukotriene synthesis and a translocation of 5… Expand

L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… Expand