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MK-886

Known as: MK 886, MK886 cpd 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

IndolesLipoxygenase Inhibitors
L 663536

Papers overview

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2010
2010
Microsomal prostaglandin E synthase‐1 and cyclooxygenase‐2 are both required for ischaemic excitotoxicity
Background and purpose:  Although both microsomal prostaglandin E synthase (mPGES)‐1 and cyclooxygenase (COX)‐2 are critical… 
2007
2007
Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells.
2004
2004
Five‐lipoxygenase‐activating protein inhibitor MK‐886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax
Background and Aim:  Products of the arachidonic acid metabolizing enzyme, 5‐lipoxygenase (5‐LOX), stimulate the growth of… 
Highly Cited
1998
Highly Cited
1998
Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells.
Highly Cited
1993
Highly Cited
1993
Platelet-activating factor and interleukin 1 are involved in colonic dysmotility in experimental colitis in rats.
Review
1992
Review
1992
5-lipoxygenase inhibitors and their anti-inflammatory activities.
Highly Cited
1992
Highly Cited
1992
Membrane association of active 5-lipoxygenase in resting cells. Evidence for novel regulation of the enzyme in the rat alveolar macrophage.
Highly Cited
1991
Highly Cited
1991
ATP‐dependent leukotriene export from mastocytoma cells
Highly Cited
1991
Highly Cited
1991
Role of leukotriene C4 in mucosal damage caused by necrotizing agents and indomethacin in the rat stomach.
Highly Cited
1990
Highly Cited
1990
MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.
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