MK-886

BACKGROUND Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections… Expand

Leukotrienes have physiological roles in innate immune responses and pathological roles in inflammatory diseases, such as asthma… Expand

BACKGROUND Recent reports point to an important role of leukotrienes in atherogenesis. Leukotrienes are produced by 5… Expand

A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the… Expand

Exocrine ductal carcinoma of the pancreas has been associated with smoking, and the tobacco-specific nitrosamine 4… Expand

Lung cancer is the leading cause of death in the United States, and it demonstrates a strong etiological association with smoking… Expand

Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene… Expand

To elucidate the role of leukotrienes (LT) in allergic asthma in humans the effect of MK-886, an LT biosynthesis inhibitor, was… Expand

LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… Expand

L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… Expand