MK-886

BACKGROUND Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections… (More)

This study evaluates the potential for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) to activate peroxisome… (More)

BACKGROUND Recent reports point to an important role of leukotrienes in atherogenesis. Leukotrienes are produced by 5… (More)

A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the… (More)

Thrombosis and inflammation involve complex platelet-leukocyte interaction, the details of which are not fully elucidated… (More)

Lung cancer is the leading cause of death in the United States, and it demonstrates a strong etiological association with smoking… (More)

To elucidate the role of leukotrienes (LT) in allergic asthma in humans the effect of MK-886, an LT biosynthesis inhibitor, was… (More)

LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… (More)

Leukotrienes (LTs) have been implicated as mediators of the inflammation and ulceration associated with ulcerative colitis and… (More)

L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… (More)