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MK-886

Known as: MK 886, MK886 cpd 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

IndolesLipoxygenase Inhibitors
L 663536

Papers overview

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Review
2008
Review
2008
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.
Highly Cited
2006
Highly Cited
2006
Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors ( , / , ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate
This study evaluates the potential for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) to activate peroxisome… 
Highly Cited
2006
Highly Cited
2006
Inhibition of five lipoxygenase activating protein (FLAP) by MK‐886 decreases atherosclerosis in apoE/LDLR‐double knockout mice
Background  Recent reports point to an important role of leukotrienes in atherogenesis. Leukotrienes are produced by 5… 
Highly Cited
1997
Highly Cited
1997
Inhibition by boswellic acids of human leukocyte elastase.
Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene… 
Highly Cited
1993
Highly Cited
1993
5‐lipoxygenase‐activating protein is an arachidonate binding protein
Highly Cited
1993
Highly Cited
1993
Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses.
To elucidate the role of leukotrienes (LT) in allergic asthma in humans the effect of MK-886, an LT biosynthesis inhibitor, was… 
Highly Cited
1990
Highly Cited
1990
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… 
Highly Cited
1990
Highly Cited
1990
MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.
Highly Cited
1990
Highly Cited
1990
Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.
Highly Cited
1989
Highly Cited
1989
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… 
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