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L 663536

Known as: L-663,536 
National Institutes of Health

Related topics

Related topics

1 relation
MK-886

Papers overview

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2014
2014
Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.
2000
2000
First Place—Resident Basic Science Award 1999: Effects of Leukotriene and Cyclo-Oxygenase Inhibition on Adaptive Bone Remodeling in the Middle Ear
Abnormal bone remodeling is associated with important otolaryngologic diseases. In such diseases, the mechanisms of osteoclastic… 
1998
1998
Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury.
1995
1995
Studies on the mechanism of PAF-induced vasopermeability in rat lungs.
1993
1993
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia
1 A study has been made of the modulation of high‐voltage activated transient and sustained calcium currents in cultured neurones… 
Review
1992
Review
1992
5-lipoxygenase inhibitors and their anti-inflammatory activities.
1992
1992
Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions.
Highly Cited
1990
Highly Cited
1990
Role of eicosanoids in PAF‐induced increases of the vascular permeability in rat airways
1 Platelet activating factor (PAF; 1.0 and 5.0 μg kg−1) injected in the tail vein of unanaesthetized rats dose‐dependently… 
1990
1990
Inhibitory effects of MK‐886 on arachidonic acid metabolism in human phagocytes
1 We have investigated the inhibitory activity of compound MK‐886 (formerly L‐663,536), an indole derivative, on 5‐lipoxygenase… 
Highly Cited
1989
Highly Cited
1989
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… 
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