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L 663536

Known as: L-663,536 
National Institutes of Health

Papers overview

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2000
2000
Abnormal bone remodeling is associated with important otolaryngologic diseases. In such diseases, the mechanisms of osteoclastic… 
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Highly Cited
1998
Highly Cited
1998
Mixed acetylboswellic acids, pentacyclic triterpenes extracted from the gum resin of Boswellia serrata Roxb., significantly… 
1998
1998
We investigated the contribution of eicosanoids, platelet-activating factor, tumor necrosis factor and nitric oxide to the… 
1993
1993
1 A study has been made of the modulation of high‐voltage activated transient and sustained calcium currents in cultured neurones… 
Highly Cited
1992
Highly Cited
1992
Erythrocyte velocity, vessel diameter, leukocyte rolling velocity, and number of adherent and emigrated leukocytes were measured… 
Review
1992
Review
1992
  • D. Batt
  • Progress in medicinal chemistry
  • 1992
  • Corpus ID: 38851238
A wide variety of agents have been reported as 5-LO inhibitors. The majority of the series appear to be lipophilic reducing… 
1992
1992
In the present study we investigated the involvement of lipid mediators in an experimental model of immune-complex alveolitis… 
Highly Cited
1990
Highly Cited
1990
1 Platelet activating factor (PAF; 1.0 and 5.0 μg kg−1) injected in the tail vein of unanaesthetized rats dose‐dependently… 
1990
1990
1 We have investigated the inhibitory activity of compound MK‐886 (formerly L‐663,536), an indole derivative, on 5‐lipoxygenase… 
Highly Cited
1989
Highly Cited
1989
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of…