L 663536

Abnormal bone remodeling is associated with important otolaryngologic diseases. In such diseases, the mechanisms of osteoclastic… Expand

Mixed acetylboswellic acids, pentacyclic triterpenes extracted from the gum resin of Boswellia serrata Roxb., significantly… Expand

We investigated the contribution of eicosanoids, platelet-activating factor, tumor necrosis factor and nitric oxide to the… Expand

1 A study has been made of the modulation of high‐voltage activated transient and sustained calcium currents in cultured neurones… Expand

Erythrocyte velocity, vessel diameter, leukocyte rolling velocity, and number of adherent and emigrated leukocytes were measured… Expand

A wide variety of agents have been reported as 5-LO inhibitors. The majority of the series appear to be lipophilic reducing… Expand

In the present study we investigated the involvement of lipid mediators in an experimental model of immune-complex alveolitis… Expand

1 Platelet activating factor (PAF; 1.0 and 5.0 μg kg−1) injected in the tail vein of unanaesthetized rats dose‐dependently… Expand

1 We have investigated the inhibitory activity of compound MK‐886 (formerly L‐663,536), an indole derivative, on 5‐lipoxygenase… Expand

L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… Expand