L 663536

We recently reported that Δ(9)-tetrahydrocannabinol (Δ(9)-THC), a major cannabinoid component in Cannabis Sativa (marijuana… (More)

Mixed acetylboswellic acids, pentacyclic triterpenes extracted from the gum resin of Boswellia serrata Roxb., significantly… (More)

We investigated the contribution of eicosanoids, platelet-activating factor, tumor necrosis factor and nitric oxide to the… (More)

The participation of lipid mediators and tumor necrosis factor (TNF) on an experimental model of immune-complex arthritis was… (More)

1. A study has been made of the modulation of high-voltage activated transient and sustained calcium currents in cultured… (More)

Erythrocyte velocity, vessel diameter, leukocyte rolling velocity, and number of adherent and emigrated leukocytes were measured… (More)

A wide variety of agents have been reported as 5-LO inhibitors. The majority of the series appear to be lipophilic reducing… (More)

1. Platelet activating factor (PAF; 1.0 and 5.0 micrograms kg-1) injected in the tail vein of unanaesthetized rats dose… (More)

1. We have investigated the inhibitory activity of compound MK-886 (formerly L-663,536), an indole derivative, on 5-lipoxygenase… (More)

L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… (More)