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Production of prostacyclin in mice following intraperitoneal injection of acetic acid, phenylbenzoquinone and zymosan: its role in the writhing response.
TLDR
Results suggest that PGI2 acts to sensitize the animal for the writhing response, and acted synergistically with acetic acid to produce writhing. Expand
Differential effects of anti-inflammatory drugs on fluid accumulation and cellular infiltration in reverse passive arthus pleurisy and carrageenan pleurisy in rats.
TLDR
It is demonstrated that the fluid and cellular responses in rat pleural inflammation can be differentially regulated by anti-inflammatory drugs depending upon the doses of antigen and antibody employed in RPAR pleurisy and the identity of the inflammatory stimulus. Expand
Comparison of several new 5-lipoxygenase inhibitors in a rat Arthus pleurisy model.
TLDR
It is demonstrated that in this rat reverse passive Arthus pleurisy model, WY-50,295 tromethamine potently and selectively inhibits 5-lipoxygenase in vivo, and possesses a longer duration of action than the other 5- Lipoxygen enzyme inhibitors employed. Expand
17-Heteroaroyl esters of corticosteroids. 2. 11 beta-Hydroxy series.
TLDR
The most potent topical antiinflammatory agents were 1e, dexamethasone 17-(2'-furoate) 21-propionate, and 2c, the 21-chloro 17-(3-furoyl) in the 9 alpha- chloro series, both being 6 times as potent as betamethAsone 17-valerate. Expand
Structure-activity relationships of a series of novel topical corticosteroids.
TLDR
The effect of various heteroaroyl groups in the 17-position of topical corticosteroids has been studied, and the most potent compounds investigated were the 21-chloro 17(2'-furoates) either in the 9 alpha,11 beta-dichloro, or in the9 alpha- chloro 11 beta-hydroxy series. Expand
Phospholipase A2-induced pleural inflammation in rats.
TLDR
It is demonstrated that exogenous PLA2 can induce pleural inflammation in the rat, and that this enzyme is released endogenously during experimental pleurisy. Expand
Synthesis and structure-activity studies of corticosteroid 17-heterocyclic aromatic esters. 1. 9 alpha, 11 beta-dichloro series.
TLDR
The preparation and topical antiinflammatory potencies of a series of 9 alpha, 11 beta-dichloro-16-methyl corticosteroid 17-heteroaryl carboxylates are described, and the most extensively studied heterocyclic acyl functionality was the 2-furoyl. Expand
Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
TLDR
The greater efficacy of WY-50,295 tromethamine in the antigen-challenged guinea pig trachea is likely to result from its combined abilities to prevent LT biosynthesis and block LTD4 receptors. Expand
Selective effects of 7 alpha-halogeno substitution on corticosteroid activity: Sch 22219 and Sch 23409.
TLDR
Both compounds possess enhanced topical antiinflammatory potency, with the potential for reduced side effects in man, and were at least equivalent to the most potent comparison corticosteroids in topical anti inflammatory activity. Expand
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