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An anorexic lipid mediator regulated by feeding
It is shown that, in rats, food deprivation markedly reduces OEA biosynthesis in the small intestine, and results indicate that OEA is a lipid mediator involved in the peripheral regulation of feeding. Expand
Cannabidiol – Recent Advances
The aim of this review is to present some of the recent publications on cannabidiol (CBD; 2), a major non‐psychoactive constituent of Cannabis, and to give a general overview. Special emphasis isExpand
Dopaminergic reward system: a short integrative review
The experimental evidence that highlights the activity of different brain nuclei modulating the mechanisms whereby dopamine biases memory towards events that are of motivational significance is reviewed. Expand
Adenosine and Sleep Homeostasis in the Basal Forebrain
In rats with 95% lesion of the BF cholinergic neurons, AD levels in the BF did not increase with 6 h of prolonged waking, and the selective adenosine A1 receptor agonist N6-cyclohexyladenosine, administered to the BF, continued to be effective in inducing sleep, indicating that the BF dendritic neurons are not essential to sleep induction. Expand
The diurnal rhythm of adenosine levels in the basal forebrain of young and old rats
It is concluded that even though old rats have more AD, a reduction in the sensitivity of the AD receptor to the ligand does not transduce the AD signal at the same strength as in young rats and may be a contributing factor to the decline in sleep drive in the elderly. Expand
Anandamide modulates sleep and memory in rats
The results suggest that the brain cannabinoid system participates in the modulation of the vigilance states and mnemonic processes and that the effect on pain perception may be a peripheral rather than a central effect. Expand
Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat.
It is postulate that all compounds are likely to be accumulated in parenchyma during the lights-off period and then, released into the CSF in order to reach target regions in turn to modulate diverse behaviors, such as feeding and sleep. Expand
Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats
CBD modulates waking via activation of neurons in the hypothalamus and DRD, both regions are apparently involved in the generation of alertness, and CBD increases DA levels as measured by microdialysis and HPLC procedures. Expand
The diurnal rhythm of hypocretin in young and old F344 rats.
In old rats there is a 10% decline in CSF HCRT-1 over the 24-hour period, which in the elderly could contribute to the increased tendency to fall asleep during the normal wake period. Expand
Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor
The present results suggest that a cannabinoid system in the PPTg may be involved in sleep regulation and that the cannabinoid effect is mediated by the CB1 receptor coupled to a PLC second messenger system. Expand