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MHC2TA protein, human

Known as: Class II Transactivator, MHC Class II Transactivator, CIITA 
MHC class II transactivator (1130 aa, ~123 kDa) is encoded by the human CIITA gene. This protein plays a role in the expression of HLA class II genes… 
National Institutes of Health

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Related topics

8 relations
Antigen PresentationCIITA geneCIITA wt AlleleCell Nucleus

Broader (1)

MHC class II transactivator protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
PU.1 Binds to a Distal Regulatory Element That Is Necessary for B Cell-Specific Expression of CIITA
The transcriptional coactivator CIITA regulates MHC class II genes. In the mouse, CIITA is expressed from three distinct… 
2010
2010
The 19S ATPase S6a (S6'/TBP1) regulates the transcription initiation of class II transactivator.
2008
2008
Loss of interferon‐γ inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post‐transcriptional as well as epigenetic regulation
Background  Abnormalities of the major histocompatibility complex (MHC) antigens by tumour cells impair the cellular immune… 
2006
2006
MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiency.
CONTEXT The polymorphism of class II HLA genes modulates the genetic risk for several endocrine autoimmune diseases. The… 
Highly Cited
2005
Highly Cited
2005
X Box-Like Sequences in the MHC Class II Region Maintain Regulatory Function1
Sequences homologous to the canonical MHC class II (MHC-II) gene X box regulatory elements were identified within the HLA-DR… 
2002
2002
DNA Alkylating Agents Alleviate Silencing of Class II Transactivator Gene Expression in L1210 Lymphoma Cells1
MHC class II (Ia) Ag expression is inversely correlated with tumorigenicity and directly correlated with immunogenicity in clones… 
2000
2000
Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.
Transcription of major histocompatibility complex (MHC) class II genes depends upon the trimeric complexes RFX and NF-Y binding… 
2000
2000
Cutting Edge: Activation of HIV-1 Transcription by the MHC Class II Transactivator1
Both macrophages and activated CD4+ T cells can be productively infected by HIV-1, and both cell types express MHC class II… 
1998
1998
Class II transactivator-independent endothelial cell MHC class II gene activation induced by lymphocyte adhesion.
NK cells induce MHC class II molecules on the surface of allogeneic endothelial cells in an adhesion-dependent, IFN-gamma… 
Highly Cited
1997
Highly Cited
1997
Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex.
Regulatory factor X (RFX) is a transcription factor that binds the conserved X1 box of MHC class II promoters and is essential… 
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