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MHC2TA protein, human

Known as: Class II Transactivator, MHC Class II Transactivator, CIITA 
MHC class II transactivator (1130 aa, ~123 kDa) is encoded by the human CIITA gene. This protein plays a role in the expression of HLA class II genes… 
National Institutes of Health

Related topics

Related topics

8 relations
Antigen PresentationCIITA geneCIITA wt AlleleCell Nucleus

Broader (1)

MHC class II transactivator protein

Papers overview

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Highly Cited
2010
Highly Cited
2010
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
The MHC class II transactivator gene (CIITA) is an important transcription factor regulating gene required for HLA class II MHC… 
2006
2006
MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiency.
CONTEXT The polymorphism of class II HLA genes modulates the genetic risk for several endocrine autoimmune diseases. The… 
Highly Cited
2005
Highly Cited
2005
X Box-Like Sequences in the MHC Class II Region Maintain Regulatory Function1
Sequences homologous to the canonical MHC class II (MHC-II) gene X box regulatory elements were identified within the HLA-DR… 
Highly Cited
2001
Highly Cited
2001
Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors.
BACKGROUND Graft vascular disease, a major cause of late graft failure in cardiac transplant patients, is associated with the… 
Highly Cited
2001
Highly Cited
2001
Cutting Edge: The Class II Transactivator Prevents Activation-Induced Cell Death by Inhibiting Fas Ligand Gene Expression1
The Fas:Fas ligand pathway is critical in regulating immune homeostasis by eliminating activated T cells that proliferated in… 
Highly Cited
2001
Highly Cited
2001
A 36-Amino-Acid Region of CIITA Is an Effective Inhibitor of CBP: Novel Mechanism of Gamma Interferon-Mediated Suppression of Collagen α2(I) and Other Promoters
ABSTRACT The class II transactivator (CIITA) is induced by gamma interferon (IFN-γ) and activates major histocompatibility… 
Highly Cited
1999
Highly Cited
1999
Differential selectivity of CIITA promoter activation by IFN-γ and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-α
Review
1999
Review
1999
The class II transactivator CIITA is a transcriptional integrator.
Highly Cited
1997
Highly Cited
1997
Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex.
Regulatory factor X (RFX) is a transcription factor that binds the conserved X1 box of MHC class II promoters and is essential… 
Highly Cited
1995
Highly Cited
1995
Specific cytotoxic T lymphocytes recognize the immediate-early transactivator Zta of Epstein-Barr virus
We identified the immediate-early transactivator Zta of Epstein-Barr virus as a target for specific cytotoxic T lymphocytes (CTL… 
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