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MG 98

Known as: MG-98, MG-98 oligonucleotide, MG98 
A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN) with potential antitumor activity. MG 98 is a highly specific… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Background: In carcinogenesis, methylation of DNA promoter regions results in inactivation of tumor-suppressing genes. MG98 was… Expand
Highly Cited
2009
Highly Cited
2009
Purpose: To assess the safety and tolerability, pharmacokinetics, and early evidence of antitumor activity of escalating doses of… Expand
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2009
2009
Purpose:To assess the safety and tolerability, pharmacokinetics, and early evidence of antitumor activity of escalating doses of… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: Epigenetic silencing via aberrant promoter DNA hypermethylation of normal genes has been described as a leukemogenic… Expand
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Review
2007
Review
2007
  • R. Amato
  • Clinical genitourinary cancer
  • 2007
  • Corpus ID: 7085807
Results of preclinical studies and clinical phase I/II trials suggest that the antisense oligodeoxynucleotide and DNA… Expand
2007
2007
 
Highly Cited
2006
Highly Cited
2006
SummaryDNA methyltransferases (DNMTs) methylate DNA, promoting local chromatin condensation and consequent repression of gene… Expand
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2005
2005
3070 Background: DNA methylation has been postulated to play an important role in tumour progression and increased DNA… Expand
Highly Cited
2004
Highly Cited
2004
Purpose: MG98 is a second generation phosphorothioate antisense oligodeoxynucleotide which is a highly specific inhibitor of… Expand
Highly Cited
2003
Highly Cited
2003
BACKGROUND Hypermethylation and inactivation of tumor suppressor genes by the enzyme DNA methyltransferase may lead to neoplastic… Expand