MG 98

Known as: MG-98, MG-98 oligonucleotide, MG98 
A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN) with potential antitumor activity. MG 98 is a highly specific… (More)
National Institutes of Health

Papers overview

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2012
2012
BACKGROUND In carcinogenesis, methylation of DNA promoter regions results in inactivation of tumor-suppressing genes. MG98 was… (More)
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2009
2009
PURPOSE To assess the safety and tolerability, pharmacokinetics, and early evidence of antitumor activity of escalating doses of… (More)
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2008
2008
PURPOSE Epigenetic silencing via aberrant promoter DNA hypermethylation of normal genes has been described as a leukemogenic… (More)
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2008
2008
Purpose: Epigenetic silencing via aberrant promoter DNA hypermethylation of normal genes has been described as a leukemogenic… (More)
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Review
2007
Review
2007
Results of preclinical studies and clinical phase I/II trials suggest that the antisense oligodeoxynucleotide and DNA… (More)
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2006
2006
SummaryDNA methyltransferases (DNMTs) methylate DNA, promoting local chromatin condensation and consequent repression of gene… (More)
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2005
2005
3070 Background: DNA methylation has been postulated to play an important role in tumour progression and increased DNA… (More)
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2003
2003
BACKGROUND Hypermethylation and inactivation of tumor suppressor genes by the enzyme DNA methyltransferase may lead to neoplastic… (More)
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2003
2003
Purpose: MG98 is a second generation phosphorothioate antisense oligodeoxynucleotide which is a highly specific inhibitor of… (More)
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2001
2001
MethylGene and MGI Pharma are codeveloping MG-98, a second-generation antisense oligonucleotide which inhibits mRNA produced by… (More)
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