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MDM4 wt Allele

Known as: DKFZp781B1423, Mouse Double Minute 4, Human Homolog of; p53-Binding Protein Gene, MRP1 
Human MDM4 wild-type allele is located in the vicinity of 1q32 and is approximately 34 kb in length. This allele, which encodes protein Mdm4, is… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular… Expand
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Highly Cited
2008
Highly Cited
2008
We have designed MI-219 as a potent, highly selective and orally active small-molecule inhibitor of the MDM2-p53 interaction. MI… Expand
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Highly Cited
2008
Highly Cited
2008
MDM2, a ubiquitin E3-ligase of the RING family, has a key role in regulating p53 abundance. During normal non-stress conditions… Expand
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Highly Cited
2007
Highly Cited
2007
The RING domain of MDM2 that is essential for its E3 ligase activity mediates binding to itself and its structural homologue MDMX… Expand
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Highly Cited
2004
Highly Cited
2004
Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or… Expand
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Highly Cited
2001
Highly Cited
2001
The p53 protein can inhibit cell cycling or induce apoptosis, and is thus a critical regulator of tumorigenesis. This protein is… Expand
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Highly Cited
2001
Highly Cited
2001
The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or apoptosis in response to various… Expand
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Highly Cited
1999
Highly Cited
1999
The N-terminus of MDM2 proto-oncoprotein interacts with p53 and down modulates p53 activity by inhibiting transcriptional… Expand
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Highly Cited
1999
Highly Cited
1999
The MDM2 oncoprotein has transforming potential that can be activated by overexpression, and it represents a critical regulator… Expand
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Highly Cited
1996
Highly Cited
1996
Here we report the isolation of a cDNA encoding a new p53-associating protein. This new protein has been called MDMX on the basis… Expand
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