MDM4 wt Allele

Known as: DKFZp781B1423, Mouse Double Minute 4, Human Homolog of; p53-Binding Protein Gene, MRP1 
Human MDM4 wild-type allele is located in the vicinity of 1q32 and is approximately 34 kb in length. This allele, which encodes protein Mdm4, is… (More)

Topic mentions per year

Topic mentions per year

1996-2017
024619962017

Papers overview

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2008
2008
The p53 tumor suppressor is a powerful growth suppressive and pro-apoptotic molecule frequently inactivated in human cancer. Many… (More)
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2006
Highly Cited
2006
Ribosomal stress such as disruption of rRNA biogenesis activates p53 by release of ribosomal proteins from the nucleoli, which… (More)
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2006
2006
The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic development. DNA damage promotes MDMX… (More)
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2006
2006
It has been shown that MDMX inhibits the activity of the tumor suppressor p53 by primarily cooperating with the p53 feedback… (More)
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2005
Highly Cited
2005
The p53 tumor suppressor is activated after DNA damage to maintain genomic stability and prevent transformation. Rapid activation… (More)
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2003
Highly Cited
2003
The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation. Mitogenic signals activate p53 by… (More)
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2003
Highly Cited
2003
Although genetic studies have demonstrated that MDMX is essential to maintain p53 activity at low levels in non-stressed cells… (More)
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2002
2002
The MDM2 homolog MDMX is an important regulator of p53 activity during embryonic development. MDMX inactivation in mice results… (More)
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1999
Highly Cited
1999
The N-terminus of MDM2 proto-oncoprotein interacts with p53 and down modulates p53 activity by inhibiting transcriptional… (More)
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1996
Highly Cited
1996
Here we report the isolation of a cDNA encoding a new p53-associating protein. This new protein has been called MDMX on the basis… (More)
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