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MDM4 wt Allele

Known as: DKFZp781B1423, Mouse Double Minute 4, Human Homolog of; p53-Binding Protein Gene, MRP1 
Human MDM4 wild-type allele is located in the vicinity of 1q32 and is approximately 34 kb in length. This allele, which encodes protein Mdm4, is… 
National Institutes of Health

Related topics

Related topics

7 relations
1q32Cell Cycle ControlMDM2 geneMDM4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects
Although cell-cycle arrest, senescence and apoptosis remain as major canonical activities of p53 in tumor suppression, the… 
Review
2017
Review
2017
Negative auto-regulators trap p53 in their web.
The transcriptional factor p53 activates the expression of a myriad of target genes involving a complicated signalling network… 
2014
2014
Ligand Binding Mode Prediction by Docking: Mdm2/Mdmx Inhibitors as a Case Study
The p53-binding domains of Mdm2 and Mdmx, two negative regulators of the tumor suppressor p53, are validated targets for cancer… 
2013
2013
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions† †Electronic supplementary information (ESI) available: Experimental details for compound…
Triarylpyrroles e.g. 4c and 4s inhibit the MDM2–p53 and MDMX–p53 protein–protein interactions. 
Review
2010
Review
2010
Small-molecule inhibitors of MDM2 as new anticancer therapeutics.
2010
2010
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild‐type CLL with a poor cytotoxic response to Nutlin‐3
tations of cryoglobulinemia: clinical and histopathologic study of seventy-two patients. Journal of the American Academy of… 
Highly Cited
2008
Highly Cited
2008
Regulation of MDMX Expression by Mitogenic Signaling
ABSTRACT MDMX is an important regulator of p53 transcriptional activity and stress response. MDMX overexpression and gene… 
Highly Cited
2007
Highly Cited
2007
MDMX Promotes Proteasomal Turnover of p21 at G1 and Early S Phases Independently of, but in Cooperation with, MDM2
ABSTRACT We have shown previously that MDM2 promotes the degradation of the cyclin-dependent kinase inhibitor p21 through a… 
2003
2003
The E2F‐1 transcription factor is negatively regulated by its interaction with the MDMX protein
Several proteins with important roles in oncogenesis have been shown to regulate the function of the E2F‐1 transcription factor… 
2002
2002
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
MDMX is a p53 binding protein, which shares a high degree of homology with MDM2, a negative regulator of the tumor suppressor p53… 
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