MDM4 gene

Known as: MDMX, Mdm4 p53 Binding Protein Homolog (Mouse) Gene, MDM4 
This gene plays a role in cell cycle arrest.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Overexpression of MDM4 (also known as MDMX or HDMX) is thought to promote tumorigenesis by decreasing p53 tumor suppressor… (More)
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Highly Cited
2007
Highly Cited
2007
The tumor suppressor p53 is inactivated by multiple mechanisms that include mutations of the p53 gene itself and increased levels… (More)
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Highly Cited
2006
Highly Cited
2006
The p53 tumor suppressor plays a key role in maintaining genomic stability and protection against malignant transformation. MDM2… (More)
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Highly Cited
2006
Highly Cited
2006
The tumor suppressor protein p53 is a transcription factor that induces G(1) arrest of the cell cycle and/or apoptosis. The… (More)
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2005
2005
The product of the HDMX (or MDM4) gene is structurally related to the MDM2 oncoprotein and is also capable of interacting with… (More)
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Highly Cited
2004
Highly Cited
2004
Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or… (More)
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Highly Cited
2003
Highly Cited
2003
Although genetic studies have demonstrated that MDMX is essential to maintain p53 activity at low levels in non-stressed cells… (More)
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Highly Cited
2002
Highly Cited
2002
We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4… (More)
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Highly Cited
1999
Highly Cited
1999
We have previously reported on the amplification and overexpression of the MDM2 proto-oncogene in a subset of malignant gliomas… (More)
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Highly Cited
1999
Highly Cited
1999
The MDM2 oncoprotein has transforming potential that can be activated by overexpression, and it represents a critical regulator… (More)
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