Skip to search formSkip to main contentSkip to account menu

MDM4 gene

Known as: MDMX, Mdm4 p53 Binding Protein Homolog (Mouse) Gene, MDM4 
This gene plays a role in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Cycle ControlMDM2 geneMDM4 wt AlleleMdm4 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Candidate genes influencing sensitivity and resistance of human glioblastoma to Semustine
Review
2010
Review
2010
Small-molecule inhibitors of MDM2 as new anticancer therapeutics.
2009
2009
Design of a novel MDM2 binding peptide based on the p53 family
p53 is a major tumor suppressor protein, that binds to, and is negatively regulated by MDM2. In tumors over expressing MDM2, p53… 
2009
2009
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.
Murine double minute 4 (MDM4) shares significant structural homology with murine double minute 2 (MDM2) and interacts and… 
Highly Cited
2008
Highly Cited
2008
Turning a scorpion toxin into an antitumor miniprotein.
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53 and are… 
Highly Cited
2008
Highly Cited
2008
Regulation of MDMX Expression by Mitogenic Signaling
ABSTRACT MDMX is an important regulator of p53 transcriptional activity and stress response. MDMX overexpression and gene… 
Highly Cited
2007
Highly Cited
2007
MDMX Promotes Proteasomal Turnover of p21 at G1 and Early S Phases Independently of, but in Cooperation with, MDM2
ABSTRACT We have shown previously that MDM2 promotes the degradation of the cyclin-dependent kinase inhibitor p21 through a… 
2007
2007
Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis
MDMX has been shown to modulate p53 in dividing cells after DNA damage. In this study, we investigated the role of MDMX in… 
Highly Cited
2005
Highly Cited
2005
Significance of HDMX‐S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
The product of the HDMX (or MDM4) gene is structurally related to the MDM2 oncoprotein and is also capable of interacting with… 
2002
2002
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
MDMX is a p53 binding protein, which shares a high degree of homology with MDM2, a negative regulator of the tumor suppressor p53… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)