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Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
It is shown that PSD-95 is regulated by the ubiquitin-proteasome pathway, and data suggest that ubiquitination of PSd-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity. Expand
Inhibition of MDM2-mediated p53 Ubiquitination and Degradation by Ribosomal Protein L5*
  • M. Dai, Hua Lu
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 22 October 2004
It is proposed that the MDM 2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53. Expand
Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition
Ectopic expression of L23 reduced MDM2-mediated p53 ubiquitination and also induced p53 activity and G1 arrest in p 53-proficient U2OS cells but not in p53-deficient Saos-2 cells, revealing that L23 is another regulator of the p53 -MDM2 feedback regulation. Expand
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
It is shown that c-Abl binds to p73 in cells, interacting through its SH3 domain with the carboxy-terminal homo-oligomerization domain of p73, and that p73 participates in the apoptotic response to DNA damage. Expand
Signaling to p53: ribosomal proteins find their way.
The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of ribosomes, and plays a crucial role in connecting deregulated cell growth with inhibition of cell division. Expand
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation and factors that promote the association of RNA Polymerase II with the preinitiation complex stimulate this activity. Expand
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
It is demonstrated that MDM2 directly inhibits p21waf1/cip1 function by reducing p21 waf1 / cip1 stability in a ubiquitin‐independent fashion. Expand
Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2
It is shown that NS regulates p53 activity through the inhibition of MDM2, and this results suggest that a p53-dependent cell cycle checkpoint monitors changes of cellular NS levels via the impediment ofMDM2 function. Expand
Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF
Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAFII31, a human TFIID TATA box – binding protein-associated factor. Expand
Ribosomal proteins: functions beyond the ribosome.
The current understanding of how ribosomal stress provokes the accumulation of ribosome-free Ribosomal proteins, as well as the ribosomesome-independent functions of ribOSomal proteins in tumorigenesis, immune signaling, and development are overviewed. Expand