Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
- M. Colledge, E. Snyder, John D. Scott
- BiologyNeuron
- 30 October 2003
Inhibition of MDM2-mediated p53 Ubiquitination and Degradation by Ribosomal Protein L5*
It is proposed that the MDM 2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53.
Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition
- M. Dai, Shelya X. Zeng, Yetao Jin, Xiao‐Xin Sun, L. David, Hua Lu
- BiologyMolecular and Cellular Biology
- 1 September 2004
Ectopic expression of L23 reduced MDM2-mediated p53 ubiquitination and also induced p53 activity and G1 arrest in p 53-proficient U2OS cells but not in p53-deficient Saos-2 cells, revealing that L23 is another regulator of the p53 -MDM2 feedback regulation.
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
- Zhi-Min Yuan, H. Shioya, D. Kufe
- Biology, ChemistryNature
- 24 June 1999
It is shown that c-Abl binds to p73 in cells, interacting through its SH3 domain with the carboxy-terminal homo-oligomerization domain of p73, and that p73 participates in the apoptotic response to DNA damage.
Signaling to p53: ribosomal proteins find their way.
- Yanping Zhang, Hua Lu
- BiologyCancer Cell
- 3 November 2009
Ribosomal proteins: functions beyond the ribosome.
- Xiaoping Zhou, Wenjuan Liao, J. Liao, P. Liao, Hua Lu
- Biology, ChemistryJournal of Molecular Cell Biology
- 1 April 2015
The current understanding of how ribosomal stress provokes the accumulation of ribosome-free Ribosomal proteins, as well as the ribosomesome-independent functions of ribOSomal proteins in tumorigenesis, immune signaling, and development are overviewed.
Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF
- M. Uesugi, O. Nyanguile, Hua Lu, A. Levine, G. Verdine
- Biology, Chemistry
- 29 August 1997
Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAFII31, a human TFIID TATA box – binding protein-associated factor.
Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2
- M. Dai, Xiao‐Xin Sun, Hua Lu
- BiologyMolecular and Cellular Biology
- 21 April 2008
It is shown that NS regulates p53 activity through the inhibition of MDM2, and this results suggest that a p53-dependent cell cycle checkpoint monitors changes of cellular NS levels via the impediment ofMDM2 function.
Nucleophosmin Is Essential for Ribosomal Protein L5 Nuclear Export
- Yue Yue Yu, L. Maggi, J. Weber
- BiologyMolecular and Cellular Biology
- 15 May 2006
It is shown that Nucleophosmin utilizes a conserved CRM1-dependent nuclear export sequence in its amino terminus to enable its shuttling between the nucleolus/nucleus and cytoplasm and demonstrating that NPM and its nuclear export provide a unique and necessary chaperoning activity to rpL5/5S.
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
- Hua Lu, L. Zawel, L. Fisher, J. Egly, D. Reinberg
- Biology, ChemistryNature
- 20 August 1992
Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation and factors that promote the association of RNA Polymerase II with the preinitiation complex stimulate this activity.
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