MDM2 gene

Known as: ONCOPROTEIN MDM2, HDM2, MDM2 
This gene plays a role in several cellular processes related to cellular viability; including the cell cycle and apoptosis.
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonable to assume that naturally… (More)
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Highly Cited
2003
Highly Cited
2003
The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is… (More)
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Highly Cited
2001
Highly Cited
2001
We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein… (More)
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Highly Cited
1998
Highly Cited
1998
The INK4a gene encodes two distinct growth inhibitors--the cyclin-dependent kinase inhibitor p16Ink4a, which is a component of… (More)
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Highly Cited
1998
Highly Cited
1998
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading… (More)
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Highly Cited
1997
Highly Cited
1997
DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms. Here we show that phosphorylation… (More)
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Highly Cited
1993
Highly Cited
1993
The human homologue of the murine double minute 2 gene (MDM2), a p53-binding protein which may act as a regulator of p53 protein… (More)
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Highly Cited
1993
Highly Cited
1993
The MDM2 (murine double minute 2) gene has recently been shown to code for a cellular protein that can complex the p53 tumor… (More)
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Highly Cited
1993
Highly Cited
1993
The p53 and MDM2 genes were analyzed in 24 human soft tissue sarcomas (11 malignant fibrous histiocytomas and 13 liposarcomas… (More)
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Highly Cited
1992
Highly Cited
1992
DESPITE extensive data linking mutations in the p53 gene to human tumorigenesis1, little is known about the cellular regulators… (More)
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