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Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study.
The apical papilla is distinctive to the pulp in terms of containing less cellular and vascular components than those in the pulp, and both SCAP and DPSCs were as potent in osteo/dentinogenic differentiation as MSCs from bone marrows, whereas they were weaker in adipogenic potential. Expand
Electrospun nanofibrous structure: a novel scaffold for tissue engineering.
- W. Li, C. Laurencin, E. Caterson, R. Tuan, F. Ko
- Materials Science, Medicine
- Journal of biomedical materials research
- 15 June 2002
A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications, which acts to support and guide cell growth. Expand
Comparison of Proliferative and Multilineage Differentiation Potential of Human Mesenchymal Stem Cells Derived from Umbilical Cord and Bone Marrow
Gene array analysis showed that HUCPVCs also expressed Wnt signaling pathway genes that have been implicated in the regulation of MSCs, which support the applicability of HU CPVCs for cell‐based therapies. Expand
Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy
A model for the regulation of MSC differentiation is proposed, and recent findings regarding theregulation of M SC differentiation are discussed. Expand
Cellular interactions and signaling in cartilage development.
In this review an extensive examination of historical and recent literature pertaining to limb development and mesenchymal condensation has been undertaken, with a focus on the development of cartilage. Expand
Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
- Catherine M Kolf, Elizabeth Cho, R. Tuan
- Biology, Medicine
- Arthritis research & therapy
- 19 February 2007
Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and… Expand
Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells
- G. Boland, Geraldine Perkins, D. Hall, R. Tuan
- Biology, Medicine
- Journal of cellular biochemistry
- 15 December 2004
The results showed that sFRP3 treatment attenuates some of the observed Wnt 3a effects on MSCs, and that inhibition of canonical Wnt signaling using a dominant negative TCF1 enhances MSC osteogenesis. Expand
Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture.
The results show that while chondrogenesis does occur in MSC-laden hydrogels, the amount of the forming matrix and measures of its mechanical properties are lower than that produced by chondrocytes under the same conditions. Expand
A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells.
The findings reported here suggest that the PCL NFS is a practical carrier for MSC transplantation, and represents a candidate scaffold for cell-based tissue engineering approaches to cartilage repair. Expand
Adult mesenchymal stem cells and cell-based tissue engineering
The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects… Expand