MCM4 protein, human

Known as: CDC21, CDC54, Cell Devision Cycle 21 Homolog 
DNA replication licensing factor MCM4 (863 aa, ~97 kDa) is encoded by the human MCM4 gene. This protein is involved in the initiation of DNA… (More)
National Institutes of Health

Related topics

Related topics

23 relations
ATP HydrolysisAdenosine TriphosphatasesCell CycleCell Cycle Control
(More)

Broader (1)

Minichromosome Maintenance Complex Component 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.
An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive form of adrenal failure, exists in a… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.
Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and nonredundant antiviral activity and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
Eukaryotic DNA replication uses kinase regulatory pathways to facilitate coordination with other processes during cell division… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
Mcm4 (minichromosome maintenance–deficient 4 homolog) encodes a subunit of the MCM2-7 complex (also known as MCM2–MCM7), the… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
Cdc7 kinase, conserved from yeasts to human, plays important roles in DNA replication. However, the mechanisms by which it… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.
Antifungal agents exert their activity through a variety of mechanisms, some of which are poorly understood. We examined changes… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2002
2002
Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
Mcm, which is composed of six structurally related subunits (Mcm2-7), is essential for eukaryotic DNA replication. A subassembly… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity.
Previous studies have identified an ATP-dependent DNA helicase activity intrinsic to the human minichromosome maintenance (MCM… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
All six minichromosome maintenance (MCM) proteins have DNA-dependent ATPase motifs in the central domain which is conserved from… (More)
Is this relevant?
1996
1996
Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.
In eukaryotes, tight regulatory mechanisms ensure the ordered progression through the cell cycle phases. The mechanisms that… (More)
Is this relevant?