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MCM4 protein, human
Known as:
CDC21
, CDC54
, Cell Devision Cycle 21 Homolog
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DNA replication licensing factor MCM4 (863 aa, ~97 kDa) is encoded by the human MCM4 gene. This protein is involved in the initiation of DNA…
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National Institutes of Health
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Related topics
Related topics
23 relations
ATP Hydrolysis
Adenosine Triphosphatases
Cell Cycle
Cell Cycle Control
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Broader (1)
Minichromosome Maintenance Complex Component 4
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex
S. Hiraga
,
G. Alvino
,
+7 authors
A. Donaldson
Genes & Development
2014
Corpus ID: 206229459
Recent evidence points to a role for Rif1 (Rap1-interacting factor) in DNA replication and genomic stability; however, the…
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Highly Cited
2012
Highly Cited
2012
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.
C. Hughes
,
L. Guasti
,
+6 authors
L. Metherell
Journal of Clinical Investigation
2012
Corpus ID: 10819096
An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive form of adrenal failure, exists in a…
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Highly Cited
2012
Highly Cited
2012
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.
L. Gineau
,
C. Cognet
,
+17 authors
E. Jouanguy
Journal of Clinical Investigation
2012
Corpus ID: 24483985
Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and nonredundant antiviral activity and…
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Highly Cited
2009
Highly Cited
2009
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
Y. Sheu
,
B. Stillman
Nature
2009
Corpus ID: 4392670
Eukaryotic DNA replication uses kinase regulatory pathways to facilitate coordination with other processes during cell division…
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Highly Cited
2007
Highly Cited
2007
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
N. Shima
,
A. Alcaraz
,
+6 authors
J. Schimenti
Nature Genetics
2007
Corpus ID: 11433033
Mcm4 (minichromosome maintenance–deficient 4 homolog) encodes a subunit of the MCM2-7 complex (also known as MCM2–MCM7), the…
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Highly Cited
2006
Highly Cited
2006
Gene expression profiling of primary cutaneous melanoma and clinical outcome.
V. Winnepenninckx
,
V. Lazar
,
+13 authors
A. Spatz
Journal of the National Cancer Institute
2006
Corpus ID: 28177344
BACKGROUND Gene expression profiling data for human primary cutaneous melanomas are scarce because of the lack of retrospective…
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Highly Cited
2005
Highly Cited
2005
Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans
Teresa T Liu
,
Robin E. B. Lee
,
+4 authors
P. D. Rogers
Antimicrobial Agents and Chemotherapy
2005
Corpus ID: 9676430
ABSTRACT Antifungal agents exert their activity through a variety of mechanisms, some of which are poorly understood. We examined…
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Highly Cited
1997
Highly Cited
1997
A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex*
Y. Ishimi
Journal of Biological Chemistry
1997
Corpus ID: 20853775
All six minichromosome maintenance (MCM) proteins have DNA-dependent ATPase motifs in the central domain which is conserved from…
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Highly Cited
1996
Highly Cited
1996
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication.
T. Krude
,
C. Musahl
,
R. Laskey
,
R. Knippers
Journal of Cell Science
1996
Corpus ID: 31027334
Members of the Mcm-protein family have recently been shown to be involved in restricting DNA replication to a single cycle in…
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Highly Cited
1987
Highly Cited
1987
The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage
L. Johnston
,
Julia H. M. White
,
A. Johnson
,
G. Lucchini
,
P. Plevani
Nucleic Acids Res.
1987
Corpus ID: 205220429
Using mitotic cultures synchronised by a feed-starve protocol or by elutriation, we have shown that the yeast DNA polymerase I…
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