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MCM4 protein, human

Known as: CDC21, CDC54, Cell Devision Cycle 21 Homolog 
DNA replication licensing factor MCM4 (863 aa, ~97 kDa) is encoded by the human MCM4 gene. This protein is involved in the initiation of DNA… Expand
National Institutes of Health

Related topics

Related topics

23 relations
ATP HydrolysisAdenosine TriphosphatasesCell CycleCell Cycle Control
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Broader (1)

Minichromosome Maintenance Complex Component 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.
Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of… Expand
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Highly Cited
2012
Highly Cited
2012
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.
An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive form of adrenal failure, exists in a… Expand
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Highly Cited
2012
Highly Cited
2012
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.
Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and nonredundant antiviral activity and… Expand
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Highly Cited
2010
Highly Cited
2010
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
Eukaryotic DNA replication uses kinase regulatory pathways to facilitate coordination with other processes during cell division… Expand
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Highly Cited
2007
Highly Cited
2007
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
Mcm4 (minichromosome maintenance–deficient 4 homolog) encodes a subunit of the MCM2-7 complex (also known as MCM2–MCM7), the… Expand
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Highly Cited
2006
Highly Cited
2006
Gene expression profiling of primary cutaneous melanoma and clinical outcome.
BACKGROUND Gene expression profiling data for human primary cutaneous melanomas are scarce because of the lack of retrospective… Expand
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Highly Cited
2006
Highly Cited
2006
Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin*♦
Cdc7 kinase, conserved from yeasts to human, plays important roles in DNA replication. However, the mechanisms by which it… Expand
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Highly Cited
2005
Highly Cited
2005
Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans
ABSTRACT Antifungal agents exert their activity through a variety of mechanisms, some of which are poorly understood. We examined… Expand
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Highly Cited
1997
Highly Cited
1997
A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex*
  • Y. Ishimi
  • The Journal of Biological Chemistry
  • 1997
    • Corpus ID: 20853775
All six minichromosome maintenance (MCM) proteins have DNA-dependent ATPase motifs in the central domain which is conserved from… Expand
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Highly Cited
1996
Highly Cited
1996
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication.
Members of the Mcm-protein family have recently been shown to be involved in restricting DNA replication to a single cycle in… Expand
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