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ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Two genes that encode proteins, Piezo1 and Piezo2, are identified, which are required for mechanically stimulated cation conductance in these cells and in cultured dorsal root ganglion neurons, and it is proposed that Piezos are components of MA cation channels.
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
A TRP Channel that Senses Cold Stimuli and Menthol
Large-scale analysis of the human and mouse transcriptomes
This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics.
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is…
Trk receptors: mediators of neurotrophin action
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
The cloning and characterization of a novel thermosensitive TRP channel, TRPV3, which is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures is described.
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
It is found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPv3 has a specific role in thermosensation.
Nociceptors: the sensors of the pain pathway.
Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.