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ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8. Expand
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
It is demonstrated that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain. Expand
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Two genes that encode proteins, Piezo1 and Piezo2, are identified, which are required for mechanically stimulated cation conductance in these cells and in cultured dorsal root ganglion neurons, and it is proposed that Piezos are components of MA cation channels. Expand
A TRP Channel that Senses Cold Stimuli and Menthol
This work describes the cloning and characterization of TRPM8, a distant relative of VR1 that is specifically expressed in a subset of pain- and temperature-sensing neurons and implicates an expanded role for this family of ion channels in somatic sensory detection. Expand
Large-scale analysis of the human and mouse transcriptomes
This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics. Expand
Trk receptors: mediators of neurotrophin action
Three-dimensional structures of the Trk receptors, in one instance in association with a neurotrophin, have revealed the structural bases underlying specificity in neurotrophIn signaling, where key intermediates are localized to different membrane compartments. Expand
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and isExpand
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
The cloning and characterization of a novel thermosensitive TRP channel, TRPV3, which is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures is described. Expand
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
It is found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPv3 has a specific role in thermosensation. Expand
Nociceptors: the sensors of the pain pathway.
Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics. Expand