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MCL1 gene

Known as: MCL1, MYELOID CELL LEUKEMIA 1, LONG ISOFORM, myeloid cell leukemia 1 
This gene is a regulator of apoptosis and plays a role in differentiation.
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisChronic Lymphocytic LeukemiaMCL1 protein, humanMYELOID CELL LEUKEMIA 1, SHORT ISOFORM

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer.
Highly Cited
2009
Highly Cited
2009
Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
Prior studies demonstrated that resistance to the ERBB1/2 inhibitor Lapatinib in HCT116 cells was mediated by increased MCL-1… 
Highly Cited
2009
Highly Cited
2009
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands*
Antagonists of anti-apoptotic Bcl-2 family members hold promise as cancer therapeutics. Apoptosis is triggered when a peptide… 
Highly Cited
2008
Highly Cited
2008
Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1 to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737
Purpose: The intrinsic drug resistance of colorectal cancers is related in part to overexpression of prosurvival Bcl-2 family… 
Highly Cited
2008
Highly Cited
2008
Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
We have defined some of the mechanisms by which the kinase inhibitor lapatinib kills HCT116 cells. Lapatinib inhibited radiation… 
Highly Cited
2008
Highly Cited
2008
Down-Regulation of Mcl-1 by Small Interfering RNA Sensitizes Resistant Melanoma Cells to Fas-Mediated Apoptosis
Resistance of malignant melanoma cells to Fas-mediated apoptosis is among the mechanisms by which they escape immune surveillance… 
Highly Cited
2007
Highly Cited
2007
Synergistic Interactions between Vorinostat and Sorafenib in Chronic Myelogenous Leukemia Cells Involve Mcl-1 and p21CIP1 Down-Regulation
Purpose: Interactions between the multikinase inhibitor sorafenib (Bay 43-9006) and the histone deacetylase inhibitor vorinostat… 
Highly Cited
2004
Highly Cited
2004
Characterisation of Mcl‐1 cleavage during apoptosis of haematopoietic cells
Mcl‐1 is essential for normal haematopoiesis, being required for lymphocyte development and maintenance. Its role in… 
Highly Cited
2000
Highly Cited
2000
Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity.
BACKGROUND Hypoxia has been shown to delay the onset of neutrophil (polymorphonuclear leukocytes [PMNs]) apoptosis. With the use… 
Highly Cited
1998
Highly Cited
1998
Expression of apoptosis regulators in cutaneous malignant melanoma.
Metastatic malignant melanoma (MM) is usually incurable and responds poorly to chemotherapy. Because many cytotoxic drugs cause… 
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