MCL1 protein, human

Known as: Bcl-2-Related Protein EAT/mcl1, mcl1/EAT, MCL1L protein, human 
Induced myeloid leukemia cell differentiation protein Mcl-1 (350 aa, ~37 kDa) is encoded by the human MCL1 gene. This protein is involved in the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell… (More)
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Highly Cited
2012
Highly Cited
2012
MCL1, which encodes the antiapoptotic protein MCL1, is among the most frequently amplified genes in human cancer. A chemical… (More)
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Highly Cited
2011
Highly Cited
2011
Microtubules have pivotal roles in fundamental cellular processes and are targets of antitubulin chemotherapeutics. Microtubule… (More)
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Highly Cited
2010
Highly Cited
2010
MCL1 is essential for the survival of stem and progenitor cells of multiple lineages, and is unique among pro-survival BCL2… (More)
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2010
2010
Antiapoptotic BCL2 family members have been implicated in the pathogenesis of acute myelogenous leukemia (AML), but the… (More)
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Highly Cited
2004
Highly Cited
2004
BCL2 family members are subject to regulation at multiple levels, providing checks on their ability to contribute to… (More)
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Highly Cited
2002
Highly Cited
2002
Myeloid cell leukemia 1 protein (MCL1) is an anti-apoptotic protein that is structurally related to Bcl-2. Unlike other Bcl-2… (More)
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Highly Cited
2001
Highly Cited
2001
Viability-promoting genes such as BCL2 play an important role in human cancer but do not directly cause aggressive tumors. BCL2… (More)
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Highly Cited
2000
Highly Cited
2000
MCL1 (ML1 myeloid cell leukemia 1), a Bcl-2 (B- cell lymphoma-leukemia 2) homologue, is known to function as an anti-apoptotic… (More)
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Highly Cited
1993
Highly Cited
1993
During their lifespan, immature cells normally pass through sequential transitions to a differentiated state and eventually… (More)
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