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MCI 186

Known as: MCI-186 
National Institutes of Health

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Related topics

1 relation

Broader (1)

phenylmethylpyrazolone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Edaravone in acute ischemic stroke, An Indian experience
Background and Objective: This study aims to evaluate the safety and efficacy of edaravone, a novel free radical scavenger, in a… 
2007
2007
MCI‐186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling
The mechanism by which MCI‐186 (3‐methyl‐1‐phenyl‐2‐prazolin‐5‐one) exerts protective effects during cerebral infarction, other… 
2006
2006
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult… 
2004
2004
EPR imaging to estimate the in vivo intracerebral reducing ability of mature rats after neonatal hypoxic-ischemic brain injury.
2003
2003
Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice.
Highly Cited
2003
Highly Cited
2003
Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats.
AIM To determine whether ONO-1078 [pranlukast, 4-oxo-8-[p-(4-phenylbutyloxy)benzoyl-amono]-2-(tetrazol-5-yl)-4H-1-benzopyran… 
2002
2002
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils
2002
2002
Contractile Responses to Reactive Oxygen Species in the Canine Basilar Artery in Vitro: Selective Inhibitory Effect of MCI-186, a new Hydroxyl Radical Scavenger
Summary. Background: Cerebral vasospasm is one of the important pathological phenomena which influence morbidity and mortality… 
2002
2002
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.
Despite growing evidence that reactive oxygen species are responsible for deleterious effects of ischemia-reperfusion (I/R… 
Highly Cited
1996
Highly Cited
1996
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart.
MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) is a newly developed antioxidant which has been shown to reduce brain edema in… 
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