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Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study
BackgroundThe prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to assess the recent prevalence of NAFLD and to predict the prevalence of nonalcoholic… Expand
Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.
- K. Yasui, E. Hashimoto, +14 authors T. Okanoue
- Clinical gastroenterology and hepatology : the…
- 1 May 2011
BACKGROUND & AIMS Nonalcoholic steatohepatitis (NASH) can progress to hepatocellular carcinoma (HCC). We aimed to characterize the clinical features of NASH patients with HCC. METHODS In a… Expand
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
- S. Watanabe, E. Hashimoto, +17 authors T. Shimosegawa
- Journal of Gastroenterology
- 24 February 2015
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in industrialized countries worldwide, and has become a serious public health issue not only in… Expand
Development of hepatic sinusoidal structure with special reference to the Ito cells
- H. Enzan, H. Himeno, Mayumi Hiroi, H. Kiyoku, T. Saibara, S. Onishi
- Medicine, Biology
- Microscopy research and technique
- 15 November 1997
To elucidate sinusoidal cell structure and function under normal conditions and their behavior in diseased settings, an understanding of their developmental aspects is needed.
Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
BackgroundA reliable and inexpensive noninvasive marker of hepatic fibrosis is required in patients with nonalcoholic fatty liver disease (NAFLD). FIB4 index (based on age, aspartate aminotransferase… Expand
Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis.
- Chikako Namikawa, Zhang Shu-ping, +8 authors S. Onishi
- Biology, Medicine
- Journal of hepatology
- 1 May 2004
BACKGROUND/AIMS The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. The aim of this study was to examine genetic influences on NASH pathogenesis. METHODS Blood samples… Expand
Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome.
BACKGROUND Obesity, hypertension, dyslipidemia, and hyperglycemia are prevalent in obstructive sleep apnea syndrome (OSAS). Metabolic syndrome, however, is defined by visceral fat obesity plus at… Expand
Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.
BACKGROUND AND STUDY AIM Malignancy in pancreatic neuroendocrine tumors (PNETs) is graded by assessing the resected specimens according to the World Health Organization (WHO) 2010 criteria. The… Expand
Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
Background Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte… Expand
Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis… Expand