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phenylmethylpyrazolone

Known as: 3H-pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-, 3-methyl-1-phenyl-2-pyrazolin-5-one, norantipyrine 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

AntipyrineFree Radical Scavengers

Narrower (1)

MCI 186
analogs & derivatives

Papers overview

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Highly Cited
2018
Highly Cited
2018
Prevalence of Amyotrophic Lateral Sclerosis — United States, 2014
Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive and fatal neuromuscular disease… 
Highly Cited
2013
Highly Cited
2013
Anti-fatigue activity of polysaccharides from the fruits of four Tibetan plateau indigenous medicinal plants.
Highly Cited
2009
Highly Cited
2009
Dissociation and Protection of the Neurovascular Unit after Thrombolysis and Reperfusion in Ischemic Rat Brain
In the ischemic brain, reperfusion with tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic… 
Highly Cited
2008
Highly Cited
2008
Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
Highly Cited
2007
Highly Cited
2007
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia
Nine-day-old harlequin (Hq) mice carrying the hypomorphic apoptosis-inducing factor (AIF)Hq mutation expressed 60% less AIF, 18… 
Highly Cited
2003
Highly Cited
2003
A Novel Free Radical Scavenger, Edarabone, Protects Against Cisplatin-Induced Acute Renal Damage in Vitro and in Vivo
Accumulating evidence suggests that enhanced peroxidative damage caused by reactive oxygen species (ROS) may contribute to the… 
Highly Cited
1997
Highly Cited
1997
Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
We investigated the effects of a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCl-186), on infarct areas… 
Highly Cited
1997
Highly Cited
1997
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia
Highly Cited
1996
Highly Cited
1996
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine, and norantipyrine formation
Highly Cited
1979
Highly Cited
1979
Assay of antipyrine and its primary metabolites in plasma, saliva and urine by high-performance liquid chromatography and some preliminary results in man.
A reversed phase system for the HPLC separation of antipyrine and its primary metabolites is described. Based on this system an… 
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