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MCF-7 Cells

Known as: Cell, MCF-7, MCF7, Michigan Cancer Foundation 7 Cells 
An adenocarcinoma cell line established in 1970 from the pleural effusion of a 69 year old Caucasian female patient with breast carcinoma.
National Institutes of Health

Related topics

Related topics

6 relations

Broader (2)

Cultured Cell LineNeoplastic Cell
MicrobiologicalProcess of secretionaspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2006
Highly Cited
2006
Melatonin inhibits both ERα activation and breast cancer cell proliferation induced by a metalloestrogen, cadmium
Abstract:  Cadmium (Cd) is a heavy metal affecting human health both through environmental and occupational exposure. There is… 
Highly Cited
2006
Highly Cited
2006
The Mucin Muc4 Potentiates Neuregulin Signaling by Increasing the Cell-surface Populations of ErbB2 and ErbB3*
Mucins provide a protective barrier for epithelial surfaces, and their overexpression in tumors has been implicated in malignancy… 
Highly Cited
2005
Highly Cited
2005
Peroxiredoxin‐I is an autoimmunogenic tumor antigen in non‐small cell lung cancer
Highly Cited
2005
Highly Cited
2005
Novel role for PDEF in epithelial cell migration and invasion.
Cell migration and invasion are two critical cellular processes that are often deregulated during tumorigenesis. To identify… 
Highly Cited
2000
Highly Cited
2000
Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.
Cellular resistance to the antifolate methotrexate (MTX) is often caused by target amplification, uptake defects, or alterations… 
Highly Cited
1999
Highly Cited
1999
Regulation of NF-κB activity by IκB-related proteins in adenocarcinoma cells
Constitutive NF-κB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of… 
Highly Cited
1997
Highly Cited
1997
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
We tested the hypothesis that there is a correlation between tumor cell efficiency in activation of matrix metalloproteinase-2… 
Highly Cited
1997
Highly Cited
1997
Alteration of the Sphingomyelin/Ceramide Pathway Is Associated with Resistance of Human Breast Carcinoma MCF7 Cells to Tumor Necrosis Factor-α-mediated Cytotoxicity*
The interference of tumor necrosis factor-α (TNF) signaling processes with the acquisition of tumor resistance to TNF was… 
Highly Cited
1989
Highly Cited
1989
Lipids in breast carcinogenesis
Excess dietary fat has been identified as a risk factor in the development of human breast carcinoma. However, the quality of fat… 
Highly Cited
1985
Highly Cited
1985
RU486, a progestin and glucocorticoid antagonist, inhibits the growth of breast cancer cells via the progesterone receptor.
The progestin and glucocorticoid antagonist RU486 was tested on the growth of several cell lines in culture. RU486 inhibited the… 
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