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Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial.
Sentinel lymph node biopsy is associated with reduced arm morbidity and better quality of life than standard axillary treatment and should be the treatment of choice for patients who have early-stage breast cancer with clinically negative nodes. Expand
Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial.
Axillary lymph node dissection and axillary radiotherapy after a positive sentinel node provide excellent and comparable axillary control for patients with T1-2 primary breast cancer and no palpable lymphadenopathy. Expand
Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group.
The working group strongly suggests that all breast cancer specialists cooperate for an optimal clinical use of this emerging technology and for future research, focusing on patient outcome as primary end-point. Expand
Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early
The data from this randomised study support the use of SNB in patients with clinically node negative breast cancer. Expand
Sentinel Node Identification Rate and Nodal Involvement in the EORTC 10981-22023 AMAROS Trial
With a 97% detection rate in this prospective international multicenter study, the SNB procedure is highly effective, especially when the combined method is used. Expand
Factors affecting failed localisation and false-negative rates of sentinel node biopsy in breast cancer – results of the ALMANAC validation phase
SLNB can accurately determine whether axillary metastases are present in patients with early stage breast cancer with clinically negative axillary nodes and both success and accuracy of SLNB are optimised by the combined use of blue dye and isotope. Expand
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer
The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of pomegranate in human breast cancer may be warranted. Expand
Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial
Anastrozole effectively reduces incidence of breast cancer in high-risk postmenopausal women, and the fact that most of the side-effects associated with oestrogen deprivation were not attributable to treatment, provides support for the use of anastroZole in post menopausal women at high risk of Breast cancer. Expand
Axillary node staging by ultrasonography and fine‐needle aspiration cytology in patients with breast cancer
This study evaluated the role of axillary ultrasonography (AUS) and fine‐needle aspiration cytology (FNAC) in preoperative staging of the axilla in patients with invasive breast cancer.
The role of the CD44/ezrin complex in cancer metastasis.
The role of CD44, ezrin family and the CD44/ezrin complex in cancer cells and their clinical impact in patients with cancer are reviewed. Expand