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Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2
Aberrant constitutive expression of c-Rel, p65 and p50 NF-κB subunits has been reported in over 90% of breast cancers. Recently, we characterized a de novo RelB NF-κB subunit synthesis pathway,… Expand
FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells
Breast cancer progression is likely a multistep process involving the activation and inactivation of a number of genes. Previously, we showed that the mRNA coding for Fra-1, a FOS family member and… Expand
Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells
Fibulin-1 is an extracellular matrix protein induced by estradiol in estrogen receptor (ER) positive ovarian cancer cell lines. Alternative splicing of fibulin-1 mRNA results in four different… Expand
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.
- O. Lanvin, S. Bianco, N. Kersual, D. Chalbos, J. Vanacker
- The Journal of biological chemistry
ICI182,780 (Fulvestrant) is a pure anti-estrogen used in adjuvant therapies of breast cancer. This compound not only inhibits the transcriptional activities of the estrogen receptor-alpha (ER alpha)… Expand
Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis.
In estrogen receptor positive human breast cancer cells, anti-estrogens inhibit the mitogenic effect of growth factors in the absence of estrogens. As activator protein-1 (AP-1) activity is one of… Expand
Mechanisms underlying differential expression of interleukin-8 in breast cancer cells
We have recently reported that interleukin-8 (IL-8) expression was inversely correlated to estrogen receptor (ER) status and was overexpressed in invasive breast cancer cells. In the present study,… Expand
Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.
Activated estrogen receptor alpha (ERalpha) modulates transcription triggered by the transcription factor activator protein-1 (AP-1), which consists of Jun-Jun homodimers and Jun-Fos heterodimers.… Expand
Hyperactivated NF-κB and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells
- 'Matladi N Ndlovu, C. Van Lint, +4 authors W. Vanden Berghe
- Medicine, Biology
- Molecular and Cellular Biology
- 17 August 2009
ABSTRACT Interleukin-6 (IL-6), involved in cancer-related inflammation, acts as an autocrine and paracrine growth factor, which promotes angiogenesis, metastasis, and subversion of immunity, and… Expand
Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms.
- N. Platet, S. Cunat, D. Chalbos, H. Rochefort, M. Garcia
- Medicine, Biology
- Molecular endocrinology
- 1 July 2000
While estrogens are mitogenic in breast cancer cells, the presence of estrogen receptor a (ERalpha) clinically indicates a favorable prognosis in breast carcinoma. To improve our understanding of… Expand
Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by Blimp-1-dependent repression of BMP-5.
- Mathilde Romagnoli, K. Belguise, +8 authors G. Sonenshein
- Biology, Medicine
- Cancer research
- 1 December 2012
Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-κB,… Expand