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MAPT gene

Known as: microtubule associated protein tau, PPP1R103, protein phosphatase 1, regulatory subunit 103 
This gene may be involved in the mediation of neuronal polarity.
National Institutes of Health

Related topics

Related topics

10 relations
Cell MovementCytokinesisFrontotemporal dementiaMicrotubule-Associated Protein Tau

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MAPT wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene
Frontotemporal dementia linked to chromosome 3 (FTD-3) is a very rare disease described in a large Danish family [1] and also in… 
Highly Cited
2004
Highly Cited
2004
Melatonin attenuates isoproterenol‐induced protein kinase A overactivation and tau hyperphosphorylation in rat brain
Abstract:  Hyperphosphorylation of microtubule‐associated protein tau at specific sites is a recognized pathological process in… 
Review
2000
Review
2000
Tau mutations in familial frontotemporal dementia.
The discovery of close to 20 different mutations in the gene encoding the microtubule-associated protein tau in frontotemporal… 
Review
2000
Review
2000
In search of γ-secretase: Presenilin at the cutting edge
The effort to solve Alzheimer's disease (AD) has led to a salutary intersection between the desire to prevent a major health… 
Highly Cited
1998
Highly Cited
1998
Direct genetic evidence for involvement of tau in progressive supranuclear palsy
Objective: To confirm whether a dinucleotide repeat sequence in an intron of the microtubule-associated protein tau is associated… 
Highly Cited
1997
Highly Cited
1997
Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21–22
An Australian family with autosomal dominant presenile nonspecific dementia was recently described. The disease results in… 
Highly Cited
1995
Highly Cited
1995
Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement.
Highly Cited
1995
Highly Cited
1995
Phosphorylation of τ Protein by Casein Kinase‐1 Converts It to an Abnormal Alzheimer‐Like State
Abstract: The microtubule‐associated protein τ is abnormally hyperphosphorylated in Alzheimer's disease. Both proline‐dependent… 
Highly Cited
1994
Highly Cited
1994
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease
Highly Cited
1994
Highly Cited
1994
Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation.
The neuronal microtubule-associated protein tau promotes microtubule assembly and has been implicated in the development of… 
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