Microtubule-Associated Protein Tau

Known as: PHF-Tau, Microtubule Associated Protein Tau, Tau Protein 
Microtubule-associated protein tau (758 aa, ~79 kDa) is encoded by the human MAPT gene. This protein may be involved in axon stability.
National Institutes of Health

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15 relations
Alzheimer's DiseaseCell MovementCytokinesisCytoskeletal Gene
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive… (More)
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Highly Cited
2010
Highly Cited
2010
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human <ce:italic>LRRK2</ce:italic> transgenic mice
Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have now emerged as the most important… (More)
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Highly Cited
2007
Highly Cited
2007
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in Alzheimer's disease and related… (More)
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Highly Cited
2004
Highly Cited
2004
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.
Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of… (More)
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Review
1997
Review
1997
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.
Alzheimer's disease (AD) is characterized by neuronal cell death and two kinds of deposits, neurofibrillary tangles (NFT) and… (More)
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Review
1996
Review
1996
Tau protein and the neurofibrillary pathology of Alzheimer's disease.
Abundant neurofibrillary tangles, neuropil threads and senile plaque neurites constitute the neurofibrillary pathology of… (More)
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Highly Cited
1996
Highly Cited
1996
Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A
Recently, we reported that a pool of protein phosphatase 2A (PP2A) is associated with microtubules. Here, we demonstrate that… (More)
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Highly Cited
1994
Highly Cited
1994
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
BACKGROUND Paired helical filaments (PHFs) are a characteristic pathological feature of Alzheimer's disease; their principal… (More)
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Highly Cited
1994
Highly Cited
1994
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
Tau from Alzheimer's disease (AD) paired helical filaments (PHF-tau) is phosphorylated at sites not found in autopsy-derived… (More)
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Highly Cited
1992
Highly Cited
1992
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
Tau with unusually slow mobilities in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was purified from the Sarkosyl… (More)
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