Microtubule-Associated Protein Tau

Known as: PHF-Tau, Microtubule Associated Protein Tau, Tau Protein 
Microtubule-associated protein tau (758 aa, ~79 kDa) is encoded by the human MAPT gene. This protein may be involved in axon stability.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive… (More)
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Highly Cited
2010
Highly Cited
2010
Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have now emerged as the most important… (More)
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Highly Cited
2007
Highly Cited
2007
Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in Alzheimer's disease and related… (More)
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Highly Cited
2004
Highly Cited
2004
Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of… (More)
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Review
1997
Review
1997
Alzheimer's disease (AD) is characterized by neuronal cell death and two kinds of deposits, neurofibrillary tangles (NFT) and… (More)
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Review
1996
Review
1996
Abundant neurofibrillary tangles, neuropil threads and senile plaque neurites constitute the neurofibrillary pathology of… (More)
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Highly Cited
1996
Highly Cited
1996
Recently, we reported that a pool of protein phosphatase 2A (PP2A) is associated with microtubules. Here, we demonstrate that… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Paired helical filaments (PHFs) are a characteristic pathological feature of Alzheimer's disease; their principal… (More)
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Highly Cited
1994
Highly Cited
1994
Tau from Alzheimer's disease (AD) paired helical filaments (PHF-tau) is phosphorylated at sites not found in autopsy-derived… (More)
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Highly Cited
1992
Highly Cited
1992
Tau with unusually slow mobilities in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was purified from the Sarkosyl… (More)
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