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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
TLDR
The phenotype of mice expressing P301L mutant tau mimics features of human tauopathies and provides a model for investigating the pathogenesis of diseases with NFT.
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
TLDR
The results indicate that either APP or Aβ influences the formation of neurofibrillary tangles and supports the hypothesis that a similar interaction occurs in Alzheimer's disease.
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
TLDR
The results suggest that microglial activation in AD may be secondary to neurodegeneration and that, once activated, microglia may participate in a local inflammatory cascade that promotes tissue damage and contributes to amyloid formation.
Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau*
TLDR
The results suggest that disease-related phosphorylation and missense mutations of tau increase association of t Tau with Fyn, and these effects are mediated through the 4R component of the tau population, these results also have implications for the FTDP-17 diseases caused by increased expression of 4R-tau.
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.
TLDR
In vitro experiments demonstrated that cathepsin D degraded alpha-synuclein very efficiently, and that limited proteolysis resulted in the generation of carboxy-terminally truncated species, suggesting that upregulation of cathep D could be an additional therapeutic strategy to lessen alpha- Synuclein burden in synucleinopathies.
Argyrophilic Grain Disease Is a Sporadic 4‐Repeat Tauopathy
TLDR
The results suggest that AGD, PSP and CBD are 4R tauopathies that share common pathologic, biochemical, and genetic characteristics.
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
TLDR
The frequent occurrence of ubiquitin-immunoreactive neurites in the CA2–3 region of the hippocampus appears to be a specific histopathologic feature of DLBD.
Multiple System Atrophy: A Sporadic Synucleinopathy
TLDR
MSA and LBD are both synucleinopathies, and they may comprise different poles of a disease spectrum that includes sporadic disorders as well as genetically determined disorders such as familial Lewy body Parkinsonism.
Widespread alterations of alpha-synuclein in multiple system atrophy.
TLDR
Findings provide evidence that modifications of alpha-synuclein in MSA may be more widespread than obvious histopathology, and these alterations may constitute a biochemical signature for the synucleinopathies.
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