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Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons.
Dual-peroxidase experiments and fluorescence double labelling demonstrated that WFA-binding structures frequently ensheath GABAergic neurons containing the calcium-binding protein parvalbumin in the areas investigated.
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
The hypothesis that perivascular solute drainage from the brain is altered both in the ageing brain and as a consequence of CAA is supported, which has implications for the success of therapeutic strategies for the treatment of AD that rely upon the health of the ageing cerebral vasculature.
Cortical neurons immunoreactive for the potassium channel Kv3.1b subunit are predominantly surrounded by perineuronal nets presumed as a buffering system for cations
Postnatal development of perineuronal nets in wild‐type mice and in a mutant deficient in tenascin‐R
It is concluded that the lack of TN‐R initially and continuously disturbs the molecular scaffolding of extracellular matrix components in perineuronal nets and may interfere with the development of the specific micromilieu of the ensheathed neurons and adjacent glial cells and may also permanently change their functional properties.
Perineuronal nets provide a polyanionic, glia‐associated form of microenvironment around certain neurons in many parts of the rat brain
It is concluded that perineuronal nets are composed of a specialized type of glia‐associated extracellular matrix rich in polyanionic groups and N‐acetylgalactosamine, similar to the ensheathment of nodes of Ranvier.
Reversible Paired Helical Filament-Like Phosphorylation of Tau Is an Adaptive Process Associated with Neuronal Plasticity in Hibernating Animals
The formation of highly phosphorylated tau, containing a number of PHF-like epitopes in torpor during hibernation was described, implicate an essential link between neuronal plasticity and PHf-like phosphorylation of tau.
Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease
Diffuse perineuronal nets and modified pyramidal cells immunoreactive for glutamate and the GABAA receptor α1 subunit form a unique entity in rat cerebral cortex
Cortical areas are revealed by distribution patterns of proteoglycan components and parvalbumin in the Mongolian gerbil and rat
Acute and long-lasting changes in extracellular-matrix chondroitin-sulphate proteoglycans induced by injection of chondroitinase ABC in the adult rat brain
- G. Brückner, A. Bringmann, W. Härtig, Gerlinde Köppe, B. Delpech, K. Brauer
- BiologyExperimental Brain Research
- 1 August 1998
It is concluded that PNs, enzymatically destroyed in the adult rat brain, can be completely reconstituted, but the restoration of their extracellular-matrix components needs several months.