Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders
- I. Litvan, J. Hauw, D. Anderson
- Medicine, PsychologyJournal of Neuropathology and Experimental…
- 1 January 1996
It was showed that with routine sampling and staining methods, neuropathologic examination alone was not fully adequate for differentiating the disorders and a clinicopathologic diagnostic criteria to improve on the NINDS criteria is proposed.
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
- J. Chapuis, F. Hansmannel, J. Lambert
- BiologyMolecular Psychiatry
- 12 February 2013
BIN1 transcript levels were increased in AD brains and a novel 3 bp insertion allele upstream of BIN1 was identified, which increased transcriptional activity in vitro and expression levels in human brain and AD risk in three independent case-control cohorts.
Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein
- C. Lasmézas, J. Deslys, D. Dormont
- BiologyScience
- 17 January 1997
Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more than 55 percent had no detectable PrPres, suggesting that a further unidentified agent may actually transmit BSE.
Neuropathological Diagnostic Criteria for Creutzfeldt‐Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases)
Neuropathological diagnostic criteria for Creutzfeldt‐Jakob disease (CJD) and other human transmissible spongiform encephalopathies (prion diseases) are proposed for the following disease entities:…
BSE transmission to macaques
- C. Lasmézas, J. Deslys, J. Hauw
- Biology, MedicineNature
- 27 June 1996
A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.
- A. Tarrade, C. Fassier, J. Melki
- BiologyHuman Molecular Genetics
- 15 December 2006
It is the first description of a human neurodegenerative disease which involves this specialized region of the axon and the link between spastin and microtubule dynamics in axons, but not in other neuronal compartments.
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease
- J. Chapuis, D. Hot, J. Lambert
- BiologyMolecular Psychiatry
- 1 November 2009
The data suggest that genetic variants in IL-33 gene may be associated with a decrease in AD risk potentially in modulating CAA formation.
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health
- C. Lasmézas, J. Fournier, J. Deslys
- BiologyProceedings of the National Academy of Sciences…
- 20 March 2001
It is shown that BSE can be transmitted from primate to primate by intravenous route in 25 months, and an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route.
Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly
- D. Zekry, C. Duyckaerts, J. Hauw
- Medicine, PsychologyActa Neuropathologica
- 6 February 2002
For similar clinical severity of dementia, there were fewer AD lesions in patients with vascular lesions than in those without vascular lesions, and the volume of infarcts and lacunes was significantly correlated with the severity of cognitive impairment.
Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease.
- B. Faucheux, N. Nillesse, Y. Agid
- BiologyProceedings of the National Academy of Sciences…
- 10 October 1995
Evidence is presented from immunohistochemical staining of postmortem human brain tissue that lactoferrin receptors are localized on neurons (perikarya, dendrites, axons), cerebral microvasculature, and, in some cases, glial cells, that lact oferrin receptor immunoreactivity on vulnerable neurons may increase intraneuronal iron levels and contribute to the degeneration of nigral dopaminergic neurons in Parkinson disease.
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