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Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.Expand
Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders
TLDR
It was showed that with routine sampling and staining methods, neuropathologic examination alone was not fully adequate for differentiating the disorders and a clinicopathologic diagnostic criteria to improve on the NINDS criteria is proposed. Expand
Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein
TLDR
Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more than 55 percent had no detectable PrPres, suggesting that a further unidentified agent may actually transmit BSE. Expand
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
TLDR
BIN1 transcript levels were increased in AD brains and a novel 3 bp insertion allele upstream of BIN1 was identified, which increased transcriptional activity in vitro and expression levels in human brain and AD risk in three independent case-control cohorts. Expand
Neuropathological Diagnostic Criteria for Creutzfeldt‐Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases)
Neuropathological diagnostic criteria for Creutzfeldt‐Jakob disease (CJD) and other human transmissible spongiform encephalopathies (prion diseases) are proposed for the following disease entities:Expand
BSE transmission to macaques
Paramedian thalamic and midbrain infarcts: Clinical and neuropathological study
TLDR
The clinical and neuropathological findings in 28 cases of paramedian thalamic and midbrain infarcts are reported and marked disturbances of consciousness and behavior associated with ocular motility changes are observed. Expand
A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.
TLDR
It is the first description of a human neurodegenerative disease which involves this specialized region of the axon and the link between spastin and microtubule dynamics in axons, but not in other neuronal compartments. Expand
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health
TLDR
It is shown that BSE can be transmitted from primate to primate by intravenous route in 25 months, and an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route. Expand
Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly
TLDR
For similar clinical severity of dementia, there were fewer AD lesions in patients with vascular lesions than in those without vascular lesions, and the volume of infarcts and lacunes was significantly correlated with the severity of cognitive impairment. Expand
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