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MAP3K10 gene

Known as: MLK2, SERINE/THREONINE KINASE, MKN28-DERIVED, NONRECEPTOR-TYPE, MKN28 KINASE 
National Institutes of Health

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MAP3K10 protein, human

Papers overview

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2013
2013
Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.
2013
2013
MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.
Highly Cited
2008
Highly Cited
2008
Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling
2008
2008
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo…
The optimization of the dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-one R(2) and R(12) positions led to the identification of… 
Highly Cited
2007
Highly Cited
2007
Dissection of a Signaling Pathway by Which Pathogen-associated Molecular Patterns Recruit the JNK and p38 MAPKs and Trigger Cytokine Release*
Pathogen-associated molecular patterns (PAMPs), molecular moieties produced by invading microbial pathogens, initiate innate… 
2003
2003
PAK interacts with NCK and MLK2 to regulate the activation of jun N‐terminal kinase
1999
1999
Expression of mixed lineage kinase 2 in germ cells of the testis
Mixed Lineage Kinase 2 is a mammalian protein kinase that activates stress‐activated protein kinases/c‐jun N‐terminal kinases… 
Highly Cited
1998
Highly Cited
1998
The MAP kinase kinase kinase MLK2 co‐localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
The MLK (mixed lineage) ser/thr kinases are most closely related to the MAP kinase kinase kinase family. In addition to a kinase… 
1998
1998
Two‐dimensional electrophoretic analysis of mixed lineage kinase 2 N‐terminal domain binding proteins
The mixed lineage kinase 2 (MLK2) protein contains several structurally distinct domains including an src homology (SH) 3 domain… 
1997
1997
Two‐dimensional electrophoretic analysis of human breast carcinoma proteins: Mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2
MLK2, a member of the mixed lineage kinase (MLK) family of protein kinases, first reported by Dorow et al. (Eur. J. Biochem. 1993… 
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