Cloning and Initial Functional Characterization of Mlk4α and Mlk4β

@inproceedings{Kashuba2011CloningAI,
  title={Cloning and Initial Functional Characterization of Mlk4α and Mlk4β},
  author={Vladimir Kashuba and Elvira V. Grigorieva and Sergei M. Kvasha and Tatiana V. Pavlova and Vladimir Grigoriev and Alexei I. Protopopov and Olga Kharchenko and Rinat Gizatullin and Alla V Rynditch and Eugene R. Zabarovsky},
  booktitle={Genomics insights},
  year={2011}
}
We have cloned a novel human mixed-lineage kinase gene, MLK4. Two alternatively spliced forms, MLK4α (580 aa) and MLK4β (1036 aa), have been identified and mapped to chromosomal band 1q42. MLK4 shows high amino acid homology to the kinase catalytic domain of MLK3 (72%), MLK1 (71%) and MLK2 (69%). Strong expression of MLK4 was detected in the human pancreas and kidneys. pCMV-MLK4β c-myc-tagged protein (human) was expressed in the cytoplasm and nucleus of transiently transfected COS-1 cells… CONTINUE READING

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