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MAP2K4 gene

Known as: MEK4, Mitogen-Activated Protein Kinase Kinase 4 Gene, SERK1 
This gene is involved in MAPK signaling.
National Institutes of Health

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Related topics

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MAP Kinase Kinase 4MAP2K1 protein, humanPhosphorylationProtein Kinase Protein Phosphorylation

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MAP2K4 wt Allele

Papers overview

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2012
2012
The protective role of polymorphism MKK4‐1304 T>G in nasopharyngeal carcinoma is modulated by Epstein–Barr virus' infection status
MKK4 is a candidate tumor suppressor, which acts as a critical mediator of Epstein–Barr Virus (EBV)‐induced c‐Jun N‐terminal… 
Review
2010
Review
2010
Diverse physiological functions of MKK4 and MKK7 during early embryogenesis.
Mitogen-activated protein kinase kinases (MAPKKs) are important components of the stress-activated protein kinase/c-Jun N… 
2006
2006
Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation.
2005
2005
Knock‐down of POSH expression is neuroprotective through down‐regulating activation of the MLK3–MKK4–JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield
We investigated the expression and subcellular localization of the multidomain protein POSH (plenty of SH3s) by… 
2004
2004
Requirement of TGF‐β receptor‐dependent activation of c‐Jun N‐terminal kinases (JNKs)/stress‐activated protein kinases (Sapks) for TGF‐β up‐regulation of the urokinase‐type plasminogen activator…
We have previously demonstrated that activation of the Ras/Mapk pathways is required for transforming growth factor β (TGF… 
Highly Cited
2002
Highly Cited
2002
Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation*
The protein serine-threonine kinase Akt mediates cell survival signaling initiated by various growth-promoting factors such as… 
2000
2000
Role of c-Jun N-terminal kinase/p38 stress signaling in 1-beta-D-arabinofuranosylcytosine-induced apoptosis.
1999
1999
Dynamic expression of SEK1 suggests multiple roles of the gene during embryogenesis and in adult brain of mice.
Highly Cited
1998
Highly Cited
1998
Immunolocalization of the mitogen‐activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system
Cell survival, death, and stress signals are transduced from the cell surface to the cytoplasm and nucleus via a cascade of… 
Highly Cited
1998
Highly Cited
1998
Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta…
The extracellular microenvironment of tumors differs from that of most normal tissues. Many tumors have relatively acidic… 
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