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MAP2K4 gene

Known as: MEK4, Mitogen-Activated Protein Kinase Kinase 4 Gene, SERK1 
This gene is involved in MAPK signaling.
National Institutes of Health

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MAP Kinase Kinase 4MAP2K1 protein, humanPhosphorylationProtein Kinase Protein Phosphorylation

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MAP2K4 wt Allele

Papers overview

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2018
2018
MicroRNA‑136 inhibits prostate cancer cell proliferation and invasion by directly targeting mitogen‑activated protein kinase kinase 4.
Prostate cancer (PCa) is the second most common type of cancer and the 6th leading cause of cancer‑associated mortality worldwide… 
Review
2013
Review
2013
Breast cancer in 2012: New drugs, new knowledge, new targets
In 2012, we increased our knowledge of the molecular portrait of breast cancer. The BOLERO-2 and CLEOPATRA trials led to the… 
Review
2010
Review
2010
Diverse physiological functions of MKK4 and MKK7 during early embryogenesis.
Mitogen-activated protein kinase kinases (MAPKKs) are important components of the stress-activated protein kinase/c-Jun N… 
2004
2004
Stress Induces Mitochondria-mediated Apoptosis Independent of SAPK/JNK Activation in Embryonic Stem Cells*
SAPK/JNK, which belongs to the family of mitogen-activated protein kinase (MAPK), is activated by many types of cellular stresses… 
2003
2003
A subdomain of MEKK1 that is critical for binding to MKK4.
2002
2002
Expression and mutation analyses of MKK4, a candidate tumour suppressor gene encoded by chromosome 17p, in human gastric adenocarcinoma.
2001
2001
Bacterial expression of activated mitogen-activated protein kinases.
1999
1999
Both p 38 a MAPK and JNK / SAPK Pathways Are Important for Induction of Nitric-oxide Synthase by Interleukin-1 b in Rat Glomerular Mesangial Cells
Interleukin 1b (IL-1b) induces expression of the inducible nitric-oxide synthase (iNOS) with concomitant release of nitric oxide… 
Highly Cited
1998
Highly Cited
1998
Immunolocalization of the mitogen‐activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system
Cell survival, death, and stress signals are transduced from the cell surface to the cytoplasm and nucleus via a cascade of… 
1998
1998
Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4.
The dual specificity kinase SEK1 (MKK4) is a direct activator of stress-activated protein kinases (SAPK/JNK) in response to… 
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