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MAP2K1 protein, human

Known as: ERK Activator Kinase 1, MEK 1, JNKK 
Dual specificity mitogen-activated protein kinase kinase 1 (393 aa, ~43 kDa) is encoded by the human MAP2K1 gene. This protein plays a role in… 
National Institutes of Health

Related topics

Related topics

49 relations
Androgen Receptor Regulation PathwayB Cell Receptor Signaling PathwayCCR3 Signaling PathwayCXCR4 Signaling Pathway

Papers overview

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2006
2006
2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Radiosensitizes Colon Carcinoma Cells through c-Jun NH2-Terminal Kinase Activation
Purpose: 2-Methoxyestradiol (2ME), an estrogen metabolite, induces apoptosis in various cell types. We investigated whether 2ME… 
2004
2004
Transient Phosphatidylinositol 3-Kinase Inhibition Protects Immature Primary Cortical Neurons from Oxidative Toxicity via Suppression of Extracellular Signal-regulated Kinase Activation*
Oxidative stress has been shown to underlie a diverse range of neuropathological conditions. Glutamate-induced oxidative toxicity… 
2004
2004
Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells.
2000
2000
5-hydroxytryptamine stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures.
5-Hydroxytryptamine (5-HT) is sequestered and released by endothelial cells, acts as an endothelial cell mitogen, promotes the… 
2000
2000
Erk and PI-3 kinase are necessary for collagen binding and actin reorganization in corneal epithelia.
PURPOSE It was recently shown that phosphatidylinositol-(PI)3 kinase is upregulated in wounded rabbit corneal epithelia… 
2000
2000
MEK1 and Erk1/2 kinases as targets for the modulation of radiation responses.
BACKGROUND The activation of mitogenic cascades via Ras, c-Raf-1, MEK-1, Erk1/2 is a hall- mark of oncogenic transformation. The… 
Highly Cited
1996
Highly Cited
1996
Chemotactic Peptide-induced Activation of MEK-2, the Predominant Isoform in Human Neutrophils
Exposure of neutrophils to a variety of agonists including chemoattractant peptides and cytokines induces degranulation and… 
1995
1995
The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line.
Ligation of membrane immunoglobulin M (mIgM) receptor in the Ramos B-cell line induced tyrosine phosphorylation of several… 
Highly Cited
1994
Highly Cited
1994
Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.
We have previously shown that the IL-6R in a growth-responsive B cell line, AF10, induces activation of mitogen-activated protein… 
Highly Cited
1994
Highly Cited
1994
Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils.
Extracellular signal-regulated kinase (Erk) (mitogen-activated protein (MAP) kinase) is rapidly activated when neutrophils are… 
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