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MAP2K4 wt Allele

Known as: MEK4, JNKK, SERK1 
Human MAP2K4 wild-type allele is located in the vicinity of 17p11.2 and is approximately 123 kb in length. This allele, which encodes dual… 
National Institutes of Health

Related topics

Related topics

28 relations
17p11.2Androgen Receptor Regulation PathwayAngiotensin II Signaling PathwayCeramide Signaling Pathway PID

Narrower (1)

MAP2K1 protein, human

Broader (1)

MAP2K4 gene

Papers overview

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Highly Cited
2012
Highly Cited
2012
Diverse Roles of JNK and MKK Pathways in the Brain
The c-Jun NH2-terminal protein kinase (JNK) plays important roles in a broad range of physiological processes. JNK is controlled… 
2009
2009
Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-κB in laryngeal squamous cell carcinoma: A potential indicator for poor prognosis
This study aimed to investigate the expression and clinical significance of mitogen-activated protein kinase kinase 4 MKK4 and… 
Highly Cited
2007
Highly Cited
2007
Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy.
2005
2005
Knock‐down of POSH expression is neuroprotective through down‐regulating activation of the MLK3–MKK4–JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield
We investigated the expression and subcellular localization of the multidomain protein POSH (plenty of SH3s) by… 
Highly Cited
2004
Highly Cited
2004
MAP2K4/MKK4 Expression in Pancreatic Cancer
MKK4 (MAP2K4/SEK1) is a member of the mitogen-activated protein kinase family, originally identified as a kinase involved in the… 
Highly Cited
2002
Highly Cited
2002
Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in endotoxin-activated microglia.
Highly Cited
2001
Highly Cited
2001
Human Neutrophil Lactoferrin trans-Activates the Matrix Metalloproteinase 1 Gene through Stress-activated MAPK Signaling Modules*
It has been proposed that human neutrophil lactoferrin (Lf) could be involved in gene expression as a DNA-binding protein after… 
1999
1999
Dynamic expression of SEK1 suggests multiple roles of the gene during embryogenesis and in adult brain of mice.
Highly Cited
1998
Highly Cited
1998
Immunolocalization of the mitogen‐activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system
Cell survival, death, and stress signals are transduced from the cell surface to the cytoplasm and nucleus via a cascade of… 
1996
1996
Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade.
We have previously shown that osmotic stress activates both the mitogen-activated protein kinase (MAPK) cascade and the stress… 
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