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MAP Kinase Kinase 4

Known as: Mitogen Activated Protein Kinase Kinase 4, JN Kinase Kinase, Jun Amino-Terminal Kinase Kinase 
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the… 
National Institutes of Health

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12 relations
In BloodJNKK activityMAP Kinase Kinase Kinase 4MAP2K1 protein, human

Papers overview

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Highly Cited
2008
Highly Cited
2008
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway*
There is accumulating evidence that mammalian target of rapamycin (mTOR)-activated pathways play important roles in cell growth… 
Highly Cited
2007
Highly Cited
2007
Adiponectin suppresses IκB kinase activation induced by tumor necrosis factor-α or high glucose in endothelial cells: role of cAMP and AMP kinase signaling
Adiponectin is a protein secreted from adipocytes that exhibits salutary effects in the vascular endothelium by signaling… 
Highly Cited
2006
Highly Cited
2006
Neuronal Angiotensin II Type 1 Receptor Upregulation in Heart Failure: Activation of Activator Protein 1 and Jun N-Terminal Kinase
Chronic heart failure (CHF) is a leading cause of mortality in developed countries. Angiotensin II (Ang II) plays an important… 
Highly Cited
2005
Highly Cited
2005
Tumor Necrosis Factor α-induced Desumoylation and Cytoplasmic Translocation of Homeodomain-interacting Protein Kinase 1 Are Critical for Apoptosis Signal-regulating Kinase 1-JNK/p38 Activation*
The apoptosis signal-regulating kinase 1 (ASK1)-JNK/p38 signaling pathway is pivotal component in cell apoptosis and can be… 
Highly Cited
2004
Highly Cited
2004
Cooperation between Fibroblast Growth Factor Receptor-4 and ErbB2 in Regulation of Cyclin D1 Translation*
Alterations in ErbB2 or fibroblast growth factor receptor-4 (FGFR-4) expression and activity occur in a significant fraction of… 
2003
2003
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
Leucine zipper-bearing kinase (LZK) is a novel member of the mixed lineage kinase (MLK) family [Sakuma, H., Ikeda, A., Oka, S… 
Highly Cited
2002
Highly Cited
2002
Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway function
The S. cerevisiae Yck2 protein is a plasma membrane-associated member of the casein kinase 1 protein kinase family that, with its… 
Highly Cited
2002
Highly Cited
2002
Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development.
Calcium/calmodulin dependent kinase II (CaMKII), PDZ-domain scaffolding protein Discs-large (DLG), immunoglobin superfamily cell… 
Highly Cited
2000
Highly Cited
2000
Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts
The Shc adaptor is responsible for coupling receptor tyrosine kinases and tyrosine kinase-associated receptors to the Ras/MAP… 
Highly Cited
1996
Highly Cited
1996
Aggregation of the FcepsilonRI on mast cells stimulates c-Jun amino-terminal kinase activity. A response inhibited by wortmannin.
Aggregation of the high-affinity Fc receptors for immunoglobulin E (IgE) (FcepsilonRI) on the surface of mast cells initiates… 
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