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MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2

Known as: MAP Kinase Signal-Integrating Kinase 2, Mnk2 
MAP kinase-interacting serine/threonine-protein kinase 2 (465 aa, ~52 kDa) is encoded by the human MKNK2 gene. This protein may be involved in… 
National Institutes of Health

Related topics

Related topics

20 relations
CDC7 protein, humanCDK10 protein, humanEnzyme GeneMAPKinase Signaling Pathway

Broader (1)

Protein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 3855: Inhibition of MNK by eFT508 reprograms T-cell signaling to promote an antitumor immune response
Mitogen-activated protein (MAP) kinase signaling cascades play a vital role in T-cell activation upon antigen recognition. MNK1… 
2018
2018
Abstract 5546: eFT508, a potent and highly selective inhibitor of MNK1 and MNK2, regulates T-cell differentiation promoting an antitumor immune response
An effective and durable T-cell response is a cornerstone of current immunotherapies. We show that eFT508, a potent, selective… 
2017
2017
Abstract 596: eFT508, a potent and highly selective inhibitor of MNK1/2 regulates immune checkpoint and cytokine expression promoting anti-tumor immunity
Dysregulated translation of messenger RNA (mRNA) plays a role in the pathogenesis of multiple solid tumors and hematological… 
2017
2017
A Phase 1-2 Dose-Escalation and Cohort- Expansion Study of eFT508, a Selective, Orally Bioavailable Inhibitor of MNK1 and MNK2, in Patients with Hematological Malignancies
Introduction Dysregulated translation of messenger RNA (mRNA) plays a role in the pathogenesis of multiple hematological and… 
2017
2017
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer
We hypothesized that MAP kinase-interacting serine/threonine kinase 2 (MNK2) may contribute to non-small cell lung cancer (NSCLC… 
2016
2016
Sulfoximine substituted quinazolines for pharmaceutical compositions US 20150005278 (A1): a patent evaluation
ABSTRACT Mnk1 and Mnk2 are protein kinases responsible for phosphorylating eIF4E, a eukaryotic initiation factor responsible for… 
2016
2016
Mnk1 and mnk2 isoindoline, aza isoindoline, dihydroindolyl Denon and dihydro-aza-in Denon inhibitors
The present invention provides compounds represented by Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable… 
2015
2015
Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery.
AIM Mitogen-activated protein kinase-interacting kinases (Mnks) are emerging anticancer targets. Mnks feature unique structural… 
Highly Cited
2007
Highly Cited
2007
MNK1 and MNK2 Regulation in HER2-overexpressing Breast Cancer Lines*
MAPK-interacting protein kinases 1 and 2 (MNK1 and MNK2) function downstream of p38 and ERK MAPK, but there are large gaps in our… 
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