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In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum.
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened in vitro for activity against Trypanosoma brucei rhodesiense, TryPanosoma cruzi, Leishmania donovani, and Plasmodium falciparum, finding notable results against all four protozoal parasites.
Triterpenoids from Vernonia auriculifera Hiern exhibit antimicrobial activity
These compounds show potential for synergistic coupling with antimicrobial agents to improve therapeutic efficiency, in the face of rising bacterial resistance.
Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis
Data obtained in the study suggest that the butanol fraction derived from the ethanolic extract of K. senegalensis root possessed excellent antioxidative as well as α-glucosidase and a-amylase inhibitory activities while chromones and/or p-anilinophenol could be the main bioactive compounds responsible for the observed activities.
Anti-diabetic effect of Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) fruit acetone fraction in a type 2 diabetes model of rats.
Elaboration of Neosamine Rings in the Biosynthesis of Neomycin and Butirosin
- F. Huang, D. Spiteller, N. Koorbanally, Yanyan Li, Nicholas M. Llewellyn, J. Spencer
- Chemistry, BiologyChembiochem : a European journal of chemical…
- 12 February 2007
The product of the btrB gene, a homologue of neo‐18 in the butirosin biosynthetic gene cluster (btr) in Bacillus circulans, exhibits the same activity as Neo‐18; this indicates that there is a similar reaction sequence in both but irosin and neomycin biosynthesis.
Antibacterial and anti-adhesion activity of the pentacyclic triterpenoids isolated from the leaves and edible fruits of Carissa macrocarpa
Four pentacyclic oleanane triterpenes (β-amyrin, methyl oleanolate, oleanolic acid and 3β-hydroxyolean-11-en-28,13β-olide) were isolated from the fruits of Carissa macrocarpawhilst the ursane…
Dacryodes edulis enhances antioxidant activities, suppresses DNA fragmentation in oxidative pancreatic and hepatic injuries; and inhibits carbohydrate digestive enzymes linked to type 2 diabetes.
Caffeine - rich infusion from Cola nitida (kola nut) inhibits major carbohydrate catabolic enzymes; abates redox imbalance; and modulates oxidative dysregulated metabolic pathways and metabolites in…
Butanol fraction of Parkia biglobosa (Jacq.) G. Don leaves enhance pancreatic β-cell functions, stimulates insulin secretion and ameliorates other type 2 diabetes-associated complications in rats.
Vanillin and vanillic acid modulate antioxidant defense system via amelioration of metabolic complications linked to Fe2+-induced brain tissues damage
- Veronica F. Salau, O. Erukainure, C. Ibeji, T. Olasehinde, N. Koorbanally, M. Islam
- Biology, ChemistryMetabolic Brain Disease
- 17 February 2020
The results insinuate that vanillin and vanillic acid confer a neuroprotective effect on oxidative brain damage, when vanillin being the most potent.