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MAD2L1 wt Allele

Known as: HSMAD2, MAD2, MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) wt Allele 
Human MAD2L1 wild-type allele is located in the vicinity of 4q27 and is approximately 8 kb in length. This allele, which encodes mitotic spindle… 
National Institutes of Health

Related topics

Related topics

5 relations
Cell CycleCell Cycle ControlMitotic Spindle CheckpointsPrometaphase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Up-regulation of Pro-apoptotic Protein Bim and Down-regulation of Anti-apoptotic Protein Mcl-1 Cooperatively Mediate Enhanced Tumor Cell Death Induced by the Combination of ERK Kinase (MEK) Inhibitor…
Background: MEK inhibitors enhance apoptosis induction by microtubule inhibitors. Results: MEK and microtubule inhibitors… 
2011
2011
Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage
BackgroundBesides Mad2’s role in carcinogenesis, recent study has shown that it is essential in cell survival. Here we found that… 
Highly Cited
2007
Highly Cited
2007
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint
The mitotic (or spindle assembly) checkpoint system ensures accurate chromosome segregation by preventing anaphase initiation… 
Highly Cited
2007
Highly Cited
2007
AMD3100 and CD26 Modulate Mobilization, Engraftment, and Survival of Hematopoietic Stem and Progenitor Cells Mediated by the SDF‐1/CXCL12‐CXCR4 Axis
Abstract:  The chemokine stromal cell‐derived factor‐1 (SDF‐1/CXCL12) and its receptor, CXCR4, are involved in a number of facets… 
2007
2007
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
We have examined the mechanism of normal DNA methyltransferase 1 (DNMT1) degradation as well as its mechanism of dysregulation in… 
2007
2007
AMD 3100 and CD 26 Modulate Mobilization , Engraftment , and Survival of Hematopoietic Stem and Progenitor Cells Mediated by the SDF-1 / CXCL 12-CXCR 4 Axis
The chemokine stromal cell-derived factor-1 (SDF-1/ CXCL12) and its receptor, CXCR4, are involved in a number of facets of the… 
Highly Cited
2006
Highly Cited
2006
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
The spindle assembly checkpoint (SAC) monitors chromosome attachment to spindle microtubules. SAC proteins operate at… 
Review
2005
Review
2005
The Mad 1 / Mad 2 Complex as a Template for Mad 2 Activation in the Spindle Assembly Checkpoint
The SAC monitors this process and delays anaphase until all chromosomes have attained bipolar attachment [1, 2]. Spindle… 
2004
2004
Activation of m-Calpain Is Required for Chromosome Alignment on the Metaphase Plate during Mitosis*
Calpains form a superfamily of Ca2+-dependent intracellular cysteine proteases with various isoforms. Two isoforms, μ- and m… 
Highly Cited
2001
Highly Cited
2001
Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase.
Mad1 was first identified in budding yeast as an essential component of the checkpoint system that monitors spindle assembly in… 
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