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The ubiquitin system
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation toExpand
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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence to the proliferative state. The ubiquitination and subsequentExpand
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The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free systems has revealed four components required for cyclin-ubiquitinExpand
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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin-proteasome system. Activation of p27 degradation is seen in proliferating cells and in manyExpand
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The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27
The cyclin-dependent kinase (CDK) inhibitor p27 is degraded in late G1 phase by the ubiquitin pathway, allowing CDK activity to drive cells into S phase. Ubiquitinylation of p27 requires itsExpand
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The ubiquitin system for protein degradation.
PERSPECTIVES AND SUMMARy 762 INTRODUCTION 762 ENZYMES OF UBIQUITIN ACTIVATION AND LIGATION 764 Ubiq u it in -Activatin g En zyme, E } . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Expand
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The Ubiquitin System
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation toExpand
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Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.
By affinity chromatography of a crude reticulocyte extract on ubiquitin-Sepharose, three enzymes required for the conjugation of ubiquitin with proteins have been isolated. One is theExpand
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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
The Cdc25A phosphatase is essential for cell-cycle progression because of its function in dephosphorylating cyclin-dependent kinases. In response to DNA damage or stalled replication, the ATM and ATRExpand
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Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase*
The cyclin-dependent kinase inhibitor p21Cip1 has important roles in the control of cell proliferation, differentiation, senescence, and apoptosis. It has been observed that p21 is a highly unstableExpand
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