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- Publications
- Influence
The ubiquitin system
- A. Hershko, A. Ciechanover, A. Varshavsky
- Chemistry, Medicine
- Nature Medicine
- 1 October 2000
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to… Expand
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
- A. Carrano, E. Eytan, A. Hershko, M. Pagano
- Biology, Medicine
- Nature Cell Biology
- 1 August 1999
Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence to the proliferative state. The ubiquitination and subsequent… Expand
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
- V. Sudakin, D. Ganoth, +5 authors A. Hershko
- Biology, Medicine
- Molecular biology of the cell
- 1 February 1995
The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free systems has revealed four components required for cyclin-ubiquitin… Expand
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
- A. Montagnoli, F. Fiore, +4 authors M. Pagano
- Biology, Medicine
- Genes & development
- 1 May 1999
The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin-proteasome system. Activation of p27 degradation is seen in proliferating cells and in many… Expand
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27
- D. Ganoth, G. Bornstein, +4 authors A. Hershko
- Biology, Medicine
- Nature Cell Biology
- 1 March 2001
The cyclin-dependent kinase (CDK) inhibitor p27 is degraded in late G1 phase by the ubiquitin pathway, allowing CDK activity to drive cells into S phase. Ubiquitinylation of p27 requires its… Expand
The ubiquitin system for protein degradation.
- A. Hershko, A. Ciechanover
- Chemistry, Medicine
- Annual review of biochemistry
- 1992
PERSPECTIVES AND SUMMARy 762 INTRODUCTION 762 ENZYMES OF UBIQUITIN ACTIVATION AND LIGATION 764 Ubiq u it in -Activatin g En zyme, E } . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .… Expand
The Ubiquitin System
- A. Hershko, A. Ciechanover
- Biology
- 1998
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to… Expand
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.
- A. Hershko, H. Heller, S. Elias, A. Ciechanover
- Chemistry, Medicine
- The Journal of biological chemistry
- 10 July 1983
By affinity chromatography of a crude reticulocyte extract on ubiquitin-Sepharose, three enzymes required for the conjugation of ubiquitin with proteins have been isolated. One is the… Expand
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
- L. Busino, M. Donzelli, +6 authors G. Draetta
- Medicine
- Nature
- 2003
The Cdc25A phosphatase is essential for cell-cycle progression because of its function in dephosphorylating cyclin-dependent kinases. In response to DNA damage or stalled replication, the ATM and ATR… Expand
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase*
- G. Bornstein, J. Bloom, Danielle Sitry-Shevah, K. Nakayama, M. Pagano, A. Hershko
- Biology, Medicine
- Journal of Biological Chemistry
- 11 July 2003
The cyclin-dependent kinase inhibitor p21Cip1 has important roles in the control of cell proliferation, differentiation, senescence, and apoptosis. It has been observed that p21 is a highly unstable… Expand